Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.
Europe
association
cancer
cohort
epidemiology
hypertension
morphology
risk factors
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
11
02
2019
revised:
23
05
2019
accepted:
14
06
2019
pubmed:
19
7
2019
medline:
23
9
2020
entrez:
19
7
2019
Statut:
ppublish
Résumé
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
Identifiants
pubmed: 31319002
doi: 10.1002/ijc.32576
pmc: PMC7115826
mid: EMS86622
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2680-2693Subventions
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C570/A16491 to EPIC-Oxford
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : Medical Research Council (UK)
ID : 1000143 to EPIC-Norfolk
Pays : International
Organisme : Medical Research Council (UK)
ID : MR/M012190/1 to EPIC-Oxford
Pays : International
Organisme : World Health Organization
ID : 001
Pays : International
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136 to EPIC-Norfolk
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C8221/A19170 to EPIC-Oxford
Pays : United Kingdom
Informations de copyright
© 2019 UICC.
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