African swine fever virus replication events and cell nucleus: New insights and perspectives.
ASFV
ASFV replication enzymes
DDR
Epigenetic signatures
Subnuclear domains
Journal
Virus research
ISSN: 1872-7492
Titre abrégé: Virus Res
Pays: Netherlands
ID NLM: 8410979
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
31
05
2019
revised:
13
07
2019
accepted:
14
07
2019
pubmed:
19
7
2019
medline:
18
7
2020
entrez:
19
7
2019
Statut:
ppublish
Résumé
African swine fever (ASF) is currently matter for major concerns in global swine industry as it is highly contagious and causes acute fatal haemorrhagic fever in domestic pigs and wild boar. The absence of effective vaccines and treatments pushes ASF control to relay on strict sanitary and stamping out measures with costly socio-economic impacts. The current epidemic scenario of fast spreading throughout Asiatic countries impels further studies on prevention and combat strategies against ASF. Herein we review knowledge on African Swine Fever Virus (ASFV) interactions with the host cell nucleus and on the functional properties of different viral DNA-replication related proteins. This entails, the confirmation of an intranuclear viral DNA replication phase, the characterization of cellular DNA damage responses (DDR), the subnuclear compartments disruption due to viral modulation, and the unravelling of the biological role of several viral proteins (A104R, I215 L, P1192R, QP509 L and Q706 L), so to contribute to underpin rational strategies for vaccine candidates development.
Identifiants
pubmed: 31319112
pii: S0168-1702(19)30364-8
doi: 10.1016/j.virusres.2019.197667
pii:
doi:
Substances chimiques
DNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
197667Informations de copyright
Copyright © 2019. Published by Elsevier B.V.