Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS).
Adolescent
Adult
Aged
Anemia, Sickle Cell
/ complications
Comorbidity
Depression
/ complications
Female
Hospitalization
/ statistics & numerical data
Humans
Length of Stay
/ statistics & numerical data
Logistic Models
Male
Middle Aged
Odds Ratio
Patient Outcome Assessment
Retrospective Studies
Risk Factors
demographics
depression
hospitalization outcomes
morbidity
mortality
sickle cell disease
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
17 Jul 2019
17 Jul 2019
Historique:
received:
29
05
2019
revised:
05
07
2019
accepted:
09
07
2019
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
3
1
2020
Statut:
epublish
Résumé
This study aimed to analyze and discern the differences in demographics and inpatient outcomes (length of stay (LOS), total charges, disease severity, and mortality) between depressed versus non-depressed sickle cell disease (SCD) patients. Comorbid depression was more prevalent among middle-aged adults (11.5%), females (10.63%), and whites (12.43%). We did not find any association between income and comorbid depression among SCD patients. After adjusting for the demographic covariates, comorbid depression remained a significant risk factor for longer LOS (mean difference -1.16 days, 95% CI -1.30 to -1.03) and higher total charges (mean difference -USD5058, 95% CI -6261 to -3855) during hospitalization. SCD with comorbid depression was also significantly associated with a higher number of chronic conditions (mean difference -2.08, 95% CI -2.13 to -2.03) and 1.5 times (95% CI 1.39 to 1.63) higher odds of major severity of illness. Comorbid depression was significantly associated with longer LOS, more severity of illness, and higher hospital charges. Healthcare providers caring for adults with SCD should consider screening for and treating comorbid depression to improve the health-related quality of life.
Identifiants
pubmed: 31319584
pii: medicina55070385
doi: 10.3390/medicina55070385
pmc: PMC6681242
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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