The Polymorphisms of the Peroxisome-Proliferator Activated Receptors' Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose.
VO2max
aerobic training
cholesterol levels
genetic predisposition
glucose tolerance
human performance
lipid metabolism
mitochondria activity
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
17 Jul 2019
17 Jul 2019
Historique:
received:
04
06
2019
revised:
09
07
2019
accepted:
15
07
2019
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
20
7
2019
Statut:
epublish
Résumé
PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. We have examined the genotype and alleles' frequencies (described in Statistical analyses revealed that Carriers of
Sections du résumé
BACKGROUND
BACKGROUND
PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage.
METHODS
METHODS
We have examined the genotype and alleles' frequencies (described in
RESULTS
RESULTS
Statistical analyses revealed that
CONCLUSIONS
CONCLUSIONS
Carriers of
Identifiants
pubmed: 31319591
pii: jcm8071043
doi: 10.3390/jcm8071043
pmc: PMC6679124
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Univerzita Karlova v Praze
ID : UNCE/HUM/032
Organisme : Polish Ministry of Science and Higher Education
ID : UM0-2012/07/B/NZ7/ 01155
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Biol Chem. 1999 Apr 9;274(15):10505-10
pubmed: 10187842
Diabetes Metab. 1999 Sep;25(3):199-211
pubmed: 10499189
Endocr Rev. 1999 Oct;20(5):649-88
pubmed: 10529898
J Lipid Res. 2000 Jun;41(6):945-52
pubmed: 10828087
Diabetologia. 2000 May;43(5):673-80
pubmed: 10855543
Pharmacogenetics. 2000 Jun;10(4):321-33
pubmed: 10862523
J Clin Invest. 2000 Jun;105(12):1723-30
pubmed: 10862787
Diabetes Metab. 2000 Nov;26(5):393-401
pubmed: 11119019
Circulation. 2002 Feb 26;105(8):950-5
pubmed: 11864924
Circulation. 2002 Mar 26;105(12):1440-5
pubmed: 11914252
Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):805-10
pubmed: 12006394
J Lipid Res. 2002 Sep;43(9):1363-79
pubmed: 12235168
J Hum Genet. 2004;49(9):482-9
pubmed: 15309680
Pharmacogenetics. 2004 Dec;14(12):823-9
pubmed: 15608561
Swiss Med Wkly. 2004 Dec 18;134(49-50):720-4
pubmed: 15635490
Nucl Recept. 2005 Nov 25;3:4
pubmed: 16309557
Eur J Appl Physiol. 2006 May;97(1):103-8
pubmed: 16506057
Mol Genet Metab. 2007 Feb;90(2):205-9
pubmed: 17129741
Diabetes. 2007 Apr;56(4):1181-6
pubmed: 17317762
Arch Intern Med. 2007 May 28;167(10):999-1008
pubmed: 17533202
Pharmacogenomics. 2008 Oct;9(10):1403-17
pubmed: 18855529
PPAR Res. 2009;2009:369602
pubmed: 19266045
Genet Epidemiol. 2009 Nov;33(7):581-98
pubmed: 19278015
Scand J Med Sci Sports. 2010 Feb;20(1):e145-50
pubmed: 19422653
Exp Mol Pathol. 2010 Feb;88(1):197-201
pubmed: 19822141
Eur J Nutr. 2011 Feb;50(1):71-9
pubmed: 20521076
J Sci Med Sport. 2011 Jan;14(1):58-64
pubmed: 20620111
J Nutrigenet Nutrigenomics. 2011;4(1):36-48
pubmed: 21487230
J Nutrigenet Nutrigenomics. 2011;4(6):354-66
pubmed: 22378291
PLoS One. 2014 Sep 08;9(9):e107171
pubmed: 25198533
PPAR Res. 2014;2014:373782
pubmed: 25371663
Biol Sport. 2014 Dec;31(4):261-6
pubmed: 25435667
Front Nutr. 2014 Jun 16;1:5
pubmed: 25988109
Cochrane Database Syst Rev. 2016 Nov 16;11:CD009753
pubmed: 27849333
J Sports Sci Med. 2016 Dec 01;15(4):616-624
pubmed: 27928207
Vascul Pharmacol. 2018 Feb;101:9-20
pubmed: 29203287
J Sport Health Sci. 2018 Oct;7(4):459-464
pubmed: 30450255
J Strength Cond Res. 2019 Aug;33(8):2057-2065
pubmed: 30985523
Biochemistry. 1993 Jun 1;32(21):5598-604
pubmed: 7684926
J Biol Chem. 1995 Jun 2;270(22):12953-6
pubmed: 7768881
Am J Physiol. 1994 Aug;267(2 Pt 2):H742-50
pubmed: 8067430
Int J Sports Med. 1993 Oct;14(7):396-400
pubmed: 8244606
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1440-4
pubmed: 8381967
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4
pubmed: 8384714
Arterioscler Thromb. 1993 May;13(5):702-11
pubmed: 8485122
Circulation. 1996 Dec 1;94(11):2837-42
pubmed: 8941110
J Biol Chem. 1997 Jan 17;272(3):2013-20
pubmed: 8999894
J Biol Chem. 1997 Mar 21;272(12):8071-6
pubmed: 9065481
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23
pubmed: 9113987
Diabetes. 1997 Aug;46(8):1319-27
pubmed: 9231657
Chem Biol. 1997 Dec;4(12):909-18
pubmed: 9427656
Mol Pharmacol. 1998 Jan;53(1):14-22
pubmed: 9443928
Diabetes Care. 1998 Apr;21(4):641-8
pubmed: 9571357
Curr Opin Chem Biol. 1997 Aug;1(2):235-41
pubmed: 9667857
Eur J Appl Physiol Occup Physiol. 1998 Jul;78(2):121-7
pubmed: 9694310
J Biol Chem. 1998 Oct 23;273(43):27988-97
pubmed: 9774413
J Med Chem. 1998 Dec 3;41(25):5020-36
pubmed: 9836620