An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration.
IKK complex
IKK, IKK
NEMO
NF-B
cholestasis
hepatocarcinogenesis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Jul 2019
17 Jul 2019
Historique:
received:
30
05
2019
revised:
05
07
2019
accepted:
16
07
2019
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
20
7
2019
Statut:
epublish
Résumé
The IκBKinase (IKK) complex represents a central signaling nexus in the TNF-dependent activation of the pro-inflammatory NF-κB pathway. However, recent studies suggested that the distinct IKK subunits (IKK, IKK, and NEMO) might withhold additional NF-κB-independent functions in inflammation and cancer. Here, we generated mice lacking all three IKK subunits in liver parenchymal cells (LPC) (IKK//NEMO
Identifiants
pubmed: 31319593
pii: cancers11070999
doi: 10.3390/cancers11070999
pmc: PMC6678501
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : H2020 European Research Council
ID : 771083
Organisme : Deutsche Krebshilfe
ID : 110043
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB-TRR57/P06
Organisme : Deutsche Forschungsgemeinschaft
ID : LU 1360/3-1
Déclaration de conflit d'intérêts
The authors declare no conflicts of interests.
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