Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus.

Aged Aged, 80 and over Amino Acids / blood Biomarkers Case-Control Studies Diabetes Complications / blood Female Humans Male Metabolomics / methods Middle Aged Pancreatic Neoplasms / blood Prevalence Prospective Studies Sensitivity and Specificity
Amino acid Biomarker Diabetes mellitus Metabolomics Pancreatic cancer

Journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 10 06 2019
revised: 04 07 2019
accepted: 12 07 2019
pubmed: 20 7 2019
medline: 29 1 2020
entrez: 20 7 2019
Statut: ppublish

Résumé

A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM. We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status. A total of 180 case-control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95). This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.

Identifiants

DOI: 10.1016/j.pan.2019.07.002 PMID: 31320196
pubmed: 31320196
pii: S1424-3903(19)30617-9
doi: 10.1016/j.pan.2019.07.002
pii:
doi:

Substances chimiques

Amino Acids 0
Biomarkers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

695-698

Informations de copyright

Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.

Auteurs

Suguru Mizuno (S)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Hiroyuki Isayama (H)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan. Electronic address: isayama-tky@umin.ac.jp.

Yousuke Nakai (Y)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Kazunaga Ishigaki (K)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Kei Saito (K)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Tatsuya Sato (T)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Tsuyoshi Takeda (T)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Ryunosuke Hakuta (R)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Tomotaka Saito (T)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Naminatsu Takahara (N)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Hirofumi Kogure (H)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Hideaki Ijichi (H)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Keisuke Tateishi (K)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Minoru Tada (M)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Nahoko Shikata (N)

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kanagawa, Japan.

Tomoyuki Tagami (T)

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kanagawa, Japan.

Shinya Kikuchi (S)

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kanagawa, Japan.

Hiroshi Yamamoto (H)

Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kanagawa, Japan.

Minoru Yamakado (M)

Department of Nursing, Ashikaga University, Tochigi, Japan; Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan.

Kazuhiko Koike (K)

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Diagnostic yield of the plasma free amino acid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Diagnostic yield of the plasma free amino acid...