Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis.
Cutaneous leishmaniasis
Drug development
Drug discovery
Formulations
Immunomodulatory drugs
In vitro assays
In vivo models
Pharmacokinetics
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
22
05
2019
revised:
16
06
2019
accepted:
17
06
2019
pubmed:
20
7
2019
medline:
29
4
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances in drug research and development (R & D) for cutaneous leishmaniasis (CL). Here we review the need for new treatments for CL, describe in vitro and in vivo assays, models and approaches taken over the past decade to establish a pathway for the discovery, and pre-clinical development of new drugs for CL. These recent advances include novel mouse models of infection using bioluminescent Leishmania, the introduction of PK/PD approaches to skin infection, and defined pre-clinical candidate profiles.
Identifiants
pubmed: 31320296
pii: S2211-3207(19)30078-8
doi: 10.1016/j.ijpddr.2019.06.003
pmc: PMC6904839
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-117Subventions
Organisme : Wellcome Trust
ID : 104976
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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