An excreted small molecule promotes C. elegans reproductive development and aging.
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
24
10
2018
accepted:
31
05
2019
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
20
11
2019
Statut:
ppublish
Résumé
Excreted small-molecule signals can bias developmental trajectories and physiology in diverse animal species. However, the chemical identity of these signals remains largely obscure. Here we report identification of an unusual N-acylated glutamine derivative, nacq#1, that accelerates reproductive development and shortens lifespan in Caenorhabditis elegans. Produced predominantly by C. elegans males, nacq#1 hastens onset of sexual maturity in hermaphrodites by promoting exit from the larval dauer diapause and by accelerating late larval development. Even at picomolar concentrations, nacq#1 shortens hermaphrodite lifespan, suggesting a trade-off between reproductive investment and longevity. Acceleration of development by nacq#1 requires chemosensation and is dependent on three homologs of vertebrate steroid hormone receptors. Unlike ascaroside pheromones, which are restricted to nematodes, fatty acylated amino acid derivatives similar to nacq#1 have been reported from humans and invertebrates, suggesting that related compounds may serve signaling functions throughout metazoa.
Identifiants
pubmed: 31320757
doi: 10.1038/s41589-019-0321-7
pii: 10.1038/s41589-019-0321-7
pmc: PMC6650165
mid: NIHMS1530686
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
838-845Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM126125
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM113692
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008500
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131877
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM088290
Pays : United States
Références
WormBook. 2007 Aug 08;:1-19
pubmed: 17988074
Neuron. 1996 Oct;17(4):719-28
pubmed: 8893028
PLoS Genet. 2017 Apr 10;13(4):e1006717
pubmed: 28394895
Genes Dev. 2008 Aug 15;22(16):2149-65
pubmed: 18708575
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9917-22
pubmed: 22665789
Nat Chem Biol. 2017 May 17;13(6):577-586
pubmed: 28514418
Cell. 2016 Jul 14;166(2):424-435
pubmed: 27374330
Science. 2014 Jan 31;343(6170):536-40
pubmed: 24356112
Science. 1991 Mar 8;251(4998):1243-6
pubmed: 2006412
Neuron. 2004 Jan 8;41(1):45-55
pubmed: 14715134
PLoS One. 2011 Mar 15;6(3):e17804
pubmed: 21423575
Annu Rev Biochem. 2011;80:885-916
pubmed: 21495846
Nat Protoc. 2018 Apr;13(4):633-651
pubmed: 29494574
Chem Biol. 2015 Jan 22;22(1):7-16
pubmed: 25484238
Nature. 2005 Feb 3;433(7025):541-5
pubmed: 15690045
BMC Bioinformatics. 2008 Nov 28;9:504
pubmed: 19040729
Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945
pubmed: 29967167
Nature. 1999 Dec 16;402(6763):804-9
pubmed: 10617200
Cell. 1995 Dec 15;83(6):835-9
pubmed: 8521507
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5522-7
pubmed: 23509272
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):653-7
pubmed: 19124770
Nature. 2008 Aug 28;454(7208):1115-8
pubmed: 18650807
Dev Biol. 1993 Jun;157(2):423-36
pubmed: 8500652
Science. 1982 Nov 5;218(4572):578-80
pubmed: 6896933
J Neurosci. 2010 Jun 2;30(22):7473-83
pubmed: 20519522
J Am Chem Soc. 2012 Jan 25;134(3):1817-24
pubmed: 22239548
Nat Prod Rep. 2015 Jul;32(7):994-1006
pubmed: 26059053
Genes Dev. 2000 Jun 15;14(12):1512-27
pubmed: 10859169
Cell. 2005 Feb 25;120(4):449-60
pubmed: 15734678
Genes Dev. 2004 Sep 1;18(17):2120-33
pubmed: 15314028
Genetics. 2017 May;206(1):55-86
pubmed: 28476862
ACS Chem Biol. 2012 Aug 17;7(8):1321-5
pubmed: 22662967
PLoS Biol. 2005 Oct;3(10):e312
pubmed: 16122351
Annu Rev Physiol. 2013;75:621-44
pubmed: 23190075
J R Soc Interface. 2009 Apr 6;6(33):377-92
pubmed: 18682364
Elife. 2017 Mar 14;6:
pubmed: 28290982
Curr Biol. 2016 Jul 11;26(13):R577-R586
pubmed: 27404253
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7708-13
pubmed: 19346493
WormBook. 2013 Jan 18;:1-22
pubmed: 23355522
Science. 2014 Jan 31;343(6170):541-4
pubmed: 24292626
Elife. 2015 Mar 30;4:
pubmed: 25822066
Genome Biol. 2001;2(8):RESEARCH0029
pubmed: 11532213
Science. 2014 Jan 31;343(6170):544-8
pubmed: 24292624
Genetics. 2000 Apr;154(4):1597-610
pubmed: 10747056
Nat Chem Biol. 2007 Jul;3(7):420-2
pubmed: 17558398
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Curr Biol. 2016 Oct 24;26(20):2827-2833
pubmed: 27618262
Nat Chem Biol. 2018 Dec;14(12):1133-1139
pubmed: 30429602
Cell Metab. 2013 Aug 6;18(2):212-24
pubmed: 23931753
Curr Biol. 2017 Sep 11;27(17):2589-2599.e3
pubmed: 28844646
Endocrinology. 1969 Mar;84(3):658-60
pubmed: 5812988
J Am Chem Soc. 2018 Feb 28;140(8):2841-2852
pubmed: 29401383
Nat Commun. 2014 Sep 11;5:4879
pubmed: 25209682
Cell. 2013 Mar 28;153(1):240-52
pubmed: 23540701