Visceral fat reduction is positively associated with blood pressure reduction in overweight or obese males but not females: an observational study.

Blood pressure Gender Meal replacement Obesity Overweight Visceral fat

Journal

Nutrition & metabolism
ISSN: 1743-7075
Titre abrégé: Nutr Metab (Lond)
Pays: England
ID NLM: 101231644

Informations de publication

Date de publication:
2019
Historique:
received: 10 12 2018
accepted: 18 06 2019
entrez: 20 7 2019
pubmed: 20 7 2019
medline: 20 7 2019
Statut: epublish

Résumé

Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between visceral fat reduction and changes in blood pressure in a group of overweight or obese Chinese individuals. An observational study was conducted with 168 participants (ChiCTR-OOC-17012000). Body composition, blood parameters and blood pressure were assessed at the beginning and end of the intervention. Males and females were categorized separately into quartiles according to changes in visceral fat during the intervention. Multiple linear regression models were used to assess the associations of changes in systolic and diastolic blood pressure with changes of visceral fat area, adjusted for potential confounders. Changes in visceral fat was significantly associated with systolic and diastolic blood pressure in men for systolic (β = 0.234, 95% CI: 0.103, 0.365; A positive association was observed between reduction in visceral fat and improvements in both systolic blood and diastolic blood pressures in males but not females in a 12-week meal replacement intervention. The Ethics Committee of Peking University Health Science Center approved the study protocol on 6 July 2017. The authors confirm that all ongoing and related trials for this intervention were carried out following the rules of the Declaration of Helsinki of 1975 and registered (ChiCTR-OOC-17012000). http://www.chictr.org.cn/showprojen.aspx?proj=20426.

Sections du résumé

BACKGROUND BACKGROUND
Visceral adiposity has been reported to play a key role in hypertension compared with other measurements of regional or general obesity. The aim of current study was to evaluate the relationship between visceral fat reduction and changes in blood pressure in a group of overweight or obese Chinese individuals.
METHODS METHODS
An observational study was conducted with 168 participants (ChiCTR-OOC-17012000). Body composition, blood parameters and blood pressure were assessed at the beginning and end of the intervention. Males and females were categorized separately into quartiles according to changes in visceral fat during the intervention. Multiple linear regression models were used to assess the associations of changes in systolic and diastolic blood pressure with changes of visceral fat area, adjusted for potential confounders.
RESULTS RESULTS
Changes in visceral fat was significantly associated with systolic and diastolic blood pressure in men for systolic (β = 0.234, 95% CI: 0.103, 0.365;
CONCLUSIONS CONCLUSIONS
A positive association was observed between reduction in visceral fat and improvements in both systolic blood and diastolic blood pressures in males but not females in a 12-week meal replacement intervention.
TRIAL REGISTRATION BACKGROUND
The Ethics Committee of Peking University Health Science Center approved the study protocol on 6 July 2017. The authors confirm that all ongoing and related trials for this intervention were carried out following the rules of the Declaration of Helsinki of 1975 and registered (ChiCTR-OOC-17012000). http://www.chictr.org.cn/showprojen.aspx?proj=20426.

Identifiants

DOI: 10.1186/s12986-019-0369-0 PMID: 31320919 PMC: PMC6617559
pubmed: 31320919
doi: 10.1186/s12986-019-0369-0
pii: 369
pmc: PMC6617559
doi:

Types de publication

Journal Article

Langues

eng

Pagination

44

Déclaration de conflit d'intérêts

Competing interestsThe authors declare that they have no competing interests.

Références

Circulation. 2015 Oct 27;132(17):1639-47
pubmed: 26294660
J Hypertens. 2016 Jan;34(1):29-31
pubmed: 26630208
Hypertension. 2010 Mar;55(3):706-14
pubmed: 20083725
Obes Rev. 2015 Feb;16(2):171-86
pubmed: 25494712
Environ Health Prev Med. 2017 Apr 4;22(1):19
pubmed: 29165123
J Am Coll Cardiol. 2014 Sep 9;64(10):997-1002
pubmed: 25190234
Diabetes Metab Syndr. 2016 Jan-Mar;10(1):4-6
pubmed: 26376586
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):602-6
pubmed: 16205459
Diabetes. 2006 Jan;55(1):249-59
pubmed: 16380500
Circulation. 2018 May 29;137(22):2357-2359
pubmed: 29844071
J Obes. 2018 Dec 26;2018:2837367
pubmed: 30687550
Int J Cardiol. 2016 Sep 15;219:204-11
pubmed: 27327508
Diabet Med. 2005 Mar;22(3):266-72
pubmed: 15717873
Public Health Nutr. 2011 Dec;14(12A):2338-45
pubmed: 22166193
N Engl J Med. 2011 Jun 23;364(25):2392-404
pubmed: 21696306
Aten Primaria. 2002 Jun 15;30(1):22-8
pubmed: 12106576
CMAJ. 2014 Nov 18;186(17):E649-57
pubmed: 25316904
J Am Heart Assoc. 2018 Apr 4;7(8):
pubmed: 29618470
Metabolism. 1987 May;36(5):502-6
pubmed: 3553852
J Hypertens. 2015 Aug;33(8):1555-62
pubmed: 26103127
Circulation. 2018 May 29;137(22):2344-2356
pubmed: 29449338
Medicine (Baltimore). 2016 Nov;95(45):e5361
pubmed: 27828861
Hypertension. 2004 Aug;44(2):127-33
pubmed: 15262911
Hypertension. 2003 Dec;42(6):1206-52
pubmed: 14656957
PLoS One. 2017 Jan 17;12(1):e0170238
pubmed: 28095471
Circulation. 2003 Oct 7;108(14):1718-23
pubmed: 12975250
Circulation. 2012 Dec 18;126(25):2983-9
pubmed: 23151344
Sci Rep. 2016 Feb 17;6:21521
pubmed: 26882876
Hypertension. 2005 Mar;45(3):356-62
pubmed: 15630041
Mayo Clin Proc. 2018 May;93(5):618-626
pubmed: 29728201
Nutr J. 2007 Jun 25;6:12
pubmed: 17592648
Ann Glob Health. 2016 Mar-Apr;82(2):227-33
pubmed: 27372527
Nutrients. 2017 May 03;9(5):
pubmed: 28467383
BMJ. 2018 Mar 29;360:k1274
pubmed: 29599212
Hypertension. 2000 Mar;35(3):807-13
pubmed: 10720599
Int J Obes (Lond). 2008 Apr;32(4):619-28
pubmed: 18180786
Lancet. 2014 Jul 5;384(9937):45-52
pubmed: 24996589
Diabetologia. 2003 Apr;46(4):459-69
pubmed: 12687327
Am J Hypertens. 2004 Oct;17(10):971-6
pubmed: 15485762
Circulation. 2008 Jul 15;118(3):230-7
pubmed: 18574045
JAMA. 2017 Jan 10;317(2):165-182
pubmed: 28097354
ISRN Obes. 2013 Apr 24;2013:473764
pubmed: 24555144
J Hypertens. 2017 Jun;35(6):1213-1218
pubmed: 28169882

Auteurs

Xiaohui Guo (X)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Yifan Xu (Y)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Hairong He (H)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Hao Cai (H)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Jianfen Zhang (J)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Yibin Li (Y)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Xinyu Yan (X)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Man Zhang (M)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Na Zhang (N)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.

Rolando L Maddela (RL)

USANA Health Sciences, Inc., 3838 W Parkway Boulevard, West Valley City, UT 84120 USA.

Guansheng Ma (G)

1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
2Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191 China.
ORCID: 0000-0001-8022-4597

Classifications MeSH