Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer.

IGF1 receptor ZYG11A endometrial cancer insulin-like growth factor-1 (IGF1) p53

Journal

Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965

Informations de publication

Date de publication:
09 Jul 2019
Historique:
received: 16 05 2019
accepted: 19 06 2019
entrez: 20 7 2019
pubmed: 20 7 2019
medline: 20 7 2019
Statut: epublish

Résumé

The insulin-like growth factors (IGF) have a key role in the development of gynecological cancers, including endometrial tumors. Uterine serous carcinoma (USC) constitutes a defined histological category among endometrial cancers. Laron syndrome (LS) is a genetic type of dwarfism that results from mutation of the growth hormone receptor (

Identifiants

pubmed: 31320996
doi: 10.18632/oncotarget.27055
pii: 27055
pmc: PMC6633887
doi:

Types de publication

Journal Article

Langues

eng

Pagination

4437-4448

Déclaration de conflit d'intérêts

CONFLICTS OF INTEREST The authors declare that they have no competing interests.

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Auteurs

Laris Achlaug (L)

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Rive Sarfstein (R)

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Karthik Nagaraj (K)

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Lena Lapkina-Gendler (L)

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Ilan Bruchim (I)

Gynecologic Oncology Division, Hillel Yaffe Medical Center, Affiliated with the Technion Institute of Technology, Haifa, Hadera 38100, Israel.

Manisha Dixit (M)

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

Zvi Laron (Z)

Endocrine and Diabetes Research Unit, Schneider Children's Medical Center, Petah Tikva 49292, Israel.

Shoshana Yakar (S)

David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA.

Haim Werner (H)

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Yoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv 69978, Israel.

Classifications MeSH