MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus.
Adult
Aged
Aged, 80 and over
Carrier Proteins
/ genetics
Fatty Liver
/ genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Genotyping Techniques
Hepacivirus
/ classification
Hepatitis C, Chronic
/ complications
Histocytochemistry
Humans
Male
Middle Aged
Polymorphism, Genetic
Young Adult
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
19
04
2019
accepted:
19
06
2019
pubmed:
20
7
2019
medline:
19
9
2019
entrez:
20
7
2019
Statut:
ppublish
Résumé
Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.
Identifiants
pubmed: 31321587
doi: 10.1007/s00705-019-04352-4
pii: 10.1007/s00705-019-04352-4
doi:
Substances chimiques
Carrier Proteins
0
microsomal triglyceride transfer protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2559-2563Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2016/19690-5