Parthenolide Inhibits the Proliferation of MDA-T32 Papillary Thyroid Carcinoma Cells in Vitro and in Mouse Tumor Xenografts and Activates Autophagy and Apoptosis by Downregulation of the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Signaling Pathway.
Animals
Apoptosis
/ drug effects
Autophagy
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
China
Humans
Mice
Mice, Nude
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Sesquiterpenes
/ metabolism
Signal Transduction
/ drug effects
TOR Serine-Threonine Kinases
/ metabolism
Thyroid Cancer, Papillary
/ drug therapy
Thyroid Neoplasms
/ drug therapy
Xenograft Model Antitumor Assays
Journal
Medical science monitor : international medical journal of experimental and clinical research
ISSN: 1643-3750
Titre abrégé: Med Sci Monit
Pays: United States
ID NLM: 9609063
Informations de publication
Date de publication:
08 Jul 2019
08 Jul 2019
Historique:
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
14
2
2020
Statut:
epublish
Résumé
<strong>BACKGROUND</strong> This study aimed to examine the effects of the sesquiterpene lactone, parthenolide, on migration, autophagy, and apoptosis of MDA-T32 human papillary thyroid carcinoma cells
Identifiants
pubmed: 31322140
pii: 915387
doi: 10.12659/MSM.915387
pmc: PMC6637819
doi:
Substances chimiques
Sesquiterpenes
0
parthenolide
2RDB26I5ZB
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
5054-5061Commentaires et corrections
Type : RetractionIn
Références
Oncogene. 2000 Aug 24;19(36):4159-69
pubmed: 10962577
Cancer Lett. 2004 May 28;208(2):143-53
pubmed: 15142672
Int J Radiat Oncol Biol Phys. 2004 Nov 15;60(4):1137-43
pubmed: 15519785
Mol Cancer Ther. 2005 Apr;4(4):587-94
pubmed: 15827332
Mol Cancer Ther. 2005 Jun;4(6):1004-12
pubmed: 15956258
Curr Med Chem Anticancer Agents. 2005 May;5(3):239-49
pubmed: 15992352
J Med Food. 2006 Spring;9(1):55-61
pubmed: 16579729
Nat Prod Rep. 2008 Jun;25(3):475-516
pubmed: 18497896
Cancer Res. 2010 Apr 1;70(7):2880-90
pubmed: 20233868
Drug Discov Today. 2010 Aug;15(15-16):668-78
pubmed: 20541036
Curr Cancer Drug Targets. 2010 Nov;10(7):705-15
pubmed: 20578985
Clin Oncol (R Coll Radiol). 2010 Aug;22(6):395-404
pubmed: 20627675
Cancer Genomics Proteomics. 2011 Jan-Feb;8(1):39-47
pubmed: 21289336
Leuk Lymphoma. 2011 Jun;52(6):1085-97
pubmed: 21417826
Molecules. 2011 Aug 09;16(8):6758-68
pubmed: 21829151
Anticancer Drugs. 2012 Oct;23(9):883-96
pubmed: 22797176
Chin Med J (Engl). 2012 Jun;125(12):2195-9
pubmed: 22884152
Cell Death Dis. 2013 Oct 31;4:e891
pubmed: 24176849
Asian Pac J Cancer Prev. 2014;15(12):4897-902
pubmed: 24998560
J Clin Endocrinol Metab. 2015 Feb;100(2):E243-52
pubmed: 25427145
Theranostics. 2015 Jan 01;5(3):302-21
pubmed: 25553117
J Nat Prod. 2016 Mar 25;79(3):629-61
pubmed: 26852623
Biotechnol Lett. 2016 Aug;38(8):1251-60
pubmed: 27099069
Cell Physiol Biochem. 2016;40(1-2):146-154
pubmed: 27855364
Cancer Res. 1971 Nov;31(11):1649-54
pubmed: 4330633
Eur J Cancer Clin Oncol. 1983 Feb;19(2):203-8
pubmed: 6681766