GATA2 Deficiency: Early Identification for Improved Clinical Outcomes.
GATA2 deficiency
acute myeloid leukemia
myelodysplastic syndrome
Journal
Clinical journal of oncology nursing
ISSN: 1538-067X
Titre abrégé: Clin J Oncol Nurs
Pays: United States
ID NLM: 9705336
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
entrez:
20
7
2019
pubmed:
20
7
2019
medline:
22
8
2020
Statut:
ppublish
Résumé
Patients with GATA2 deficiency present with nontuberculous mycobacterial infections, severe viral infections (particularly refractory human papillomavirus disease), lymphedema, myelodysplastic syndrome (MDS), and acute myeloid leukemia. Patients with GATA2 deficiency who undergo allogeneic hematopoietic stem cell transplantation prior to the development of life-threatening infections or cytogenetic abnormalities may have optimal clinical outcomes. The aim of this article is to determine ways in which oncology nurses can identify GATA2 deficiency in patients early and optimize treatment decisions. A case study is presented of a 33-year-old man with recurrent infections and MDS and his two sons, all of whom were found to have the same GATA2 mutation. Oncology nurses play an important role in early detection and identification by interviewing patients and obtaining a complete and thorough family history.
Sections du résumé
BACKGROUND
Patients with GATA2 deficiency present with nontuberculous mycobacterial infections, severe viral infections (particularly refractory human papillomavirus disease), lymphedema, myelodysplastic syndrome (MDS), and acute myeloid leukemia. Patients with GATA2 deficiency who undergo allogeneic hematopoietic stem cell transplantation prior to the development of life-threatening infections or cytogenetic abnormalities may have optimal clinical outcomes.
OBJECTIVES
The aim of this article is to determine ways in which oncology nurses can identify GATA2 deficiency in patients early and optimize treatment decisions.
METHODS
A case study is presented of a 33-year-old man with recurrent infections and MDS and his two sons, all of whom were found to have the same GATA2 mutation.
FINDINGS
Oncology nurses play an important role in early detection and identification by interviewing patients and obtaining a complete and thorough family history.
Identifiants
pubmed: 31322613
doi: 10.1188/19.CJON.417-422
pmc: PMC8549740
mid: NIHMS1743153
doi:
Substances chimiques
GATA2 Transcription Factor
0
GATA2 protein, human
0
Types de publication
Case Reports
Journal Article
Langues
eng
Pagination
417-422Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA SC010384
Pays : United States
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