Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution.
Adenoviruses, Human
/ drug effects
Animals
Capsid Proteins
/ chemistry
Dendrimers
/ chemistry
Genetic Vectors
/ chemistry
Host-Pathogen Interactions
/ drug effects
Humans
Hydrophobic and Hydrophilic Interactions
/ drug effects
Liver
/ chemistry
Polymers
/ chemistry
Receptors, Virus
/ antagonists & inhibitors
Transduction, Genetic
adenovirus
amphiphilic surface patches
dendrimer corona
dendrimer−virus complexes
gene delivery
gene therapy
polyphenylene dendrimer
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
27 08 2019
27 08 2019
Historique:
pubmed:
20
7
2019
medline:
26
8
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions. To emulate such distinct surface patterns on macromolecules, we used rigid spherical synthetic dendrimers (polyphenylene dendrimers) to provide controlled amphiphilic surface patches with molecular precision. We identified an optimal spatial arrangement of these patches on certain dendrimers that enabled their interaction with human adenovirus 5 (Ad5). Patchy dendrimers bound to the surface of Ad5 formed a synthetic polymer corona that greatly altered various host interactions of Ad5 as well as
Identifiants
pubmed: 31322856
doi: 10.1021/acsnano.9b01484
pmc: PMC6716120
doi:
Substances chimiques
Capsid Proteins
0
Dendrimers
0
Polymers
0
Receptors, Virus
0
adenovirus receptor
0
polyphenylene sulfide
9016-75-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8749-8759Commentaires et corrections
Type : ErratumIn
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