Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort.
Adolescent
Adult
Africa
Aged
Aged, 80 and over
Anti-Retroviral Agents
/ administration & dosage
Antigens, CD
/ analysis
Cross-Sectional Studies
Female
HIV Infections
/ drug therapy
Humans
Immunophenotyping
Inflammation
/ pathology
Male
Middle Aged
Monocytes
/ chemistry
Sustained Virologic Response
Young Adult
HIV infection
immune activation
immune responses
long-term antiretroviral therapy
sub-Saharan Africa
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
26 09 2019
26 09 2019
Historique:
received:
20
03
2019
accepted:
03
07
2019
pubmed:
20
7
2019
medline:
20
5
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
Monocyte dysfunction may persist during antiretroviral therapy (ART). Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function. Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively). Further investigation is required to understand drivers of persistent monocyte activation and dysfunction.
Sections du résumé
BACKGROUND
Monocyte dysfunction may persist during antiretroviral therapy (ART).
METHODS
Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function.
RESULTS
Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively).
CONCLUSIONS
Further investigation is required to understand drivers of persistent monocyte activation and dysfunction.
Identifiants
pubmed: 31323092
pii: 5536380
doi: 10.1093/infdis/jiz320
pmc: PMC6761975
doi:
Substances chimiques
Anti-Retroviral Agents
0
Antigens, CD
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1414-1419Subventions
Organisme : Wellcome Trust
ID : 107743/Z/15/Z
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
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