Piriform cortex ictogenicity in vitro.

Animals In Vitro Techniques Piriform Cortex Seizures

Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
11 2019
Historique:
received: 01 02 2019
revised: 07 05 2019
accepted: 15 07 2019
pubmed: 20 7 2019
medline: 29 2 2020
entrez: 20 7 2019
Statut: ppublish

Résumé

The piriform cortex is recognized to play critical roles in focal ictogenesis, both in animal models and in humans. We review here the contribution of in vitro studies performed on rodent brain tissue that were aimed at understanding the ictogenic properties of the piriform cortex and the contiguous olfactory areas. During in vitro experiments, epileptiform events can be easily generated in the piriform area by diverse pro-convulsive drugs (4-aminopyridine, bicuculline, picrotoxin) or by electrical stimulation. Simultaneous intracellular and field potential recordings performed on in vitro preparations, which include brain slices of rats and mice and the isolated brains of guinea pigs, demonstrated that both the piriform cortex proper and the endopiriform nucleus (also considered part of the piriform area) generate interictal spikes, high-frequency oscillations and seizure-like activities that mimic focal discharges. These findings were confirmed both by optical recordings of intrinsic signals coupled with brain activity and by fast imaging of optical signals generated by voltage-sensitive dyes. Overall, these studies demonstrated that epileptiform discharges effectively propagate from the piriform structures to the limbic regions, supporting the conditions for secondarily generalized ictogenesis.

Identifiants

DOI: 10.1016/j.expneurol.2019.113014 PMID: 31323250
pubmed: 31323250
pii: S0014-4886(19)30163-3
doi: 10.1016/j.expneurol.2019.113014
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

113014

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Marco de Curtis (M)

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. Electronic address: marco.decurtis@istituto-besta.it.

Laura Uva (L)

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

Maxime Lévesque (M)

Montreal Neurological Institute, McGill University, Montréal, Qc, Canada.

Gerardo Biella (G)

Università di Pavia, Department of Biology, Biotechnology Lazzaro Spallanzani, Italy.

Massimo Avoli (M)

Montreal Neurological Institute, McGill University, Montréal, Qc, Canada; Facoltà di Medicina e Odontoiatria, Sapienza Università di Roma, Roma, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Piriform cortex ictogenicity in vitro.
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Piriform cortex ictogenicity in vitro.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex olfactif › Cortex piriforme › Piriform cortex ictogenicity in vitro.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Piriform cortex ictogenicity in vitro.