Aneurysm Formation, Growth, and Rupture: The Biology and Physics of Cerebral Aneurysms.
Cerebral aneurysms
Flow dynamics
Inflammation
Intracranial aneurysms
Wall shear stress
Journal
World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
06
06
2019
revised:
08
07
2019
accepted:
09
07
2019
pubmed:
20
7
2019
medline:
24
1
2020
entrez:
20
7
2019
Statut:
ppublish
Résumé
Cerebral aneurysms (CAs) are characterized by a pathological wall structure with internal elastic lamina and media disruption, which leads to focal weakened pouches of the arterial wall. The prevalence of unruptured CAs has been estimated to be 2%-5% in the general population. During the past few decades, the pathophysiological mechanisms behind the formation, growth, and rupture of CAs have been the focus of numerous research studies. In the present review, we have summarized the inflammatory pathways, genetics, and risk factors for the formation, growth, and rupture of CAs. In addition, we have discussed the concepts of geometric indexes, flow patterns, and fluid dynamics that govern CA development.
Identifiants
pubmed: 31323409
pii: S1878-8750(19)31999-0
doi: 10.1016/j.wneu.2019.07.093
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
277-284Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.