Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats.
Animals
Chemical and Drug Induced Liver Injury
/ etiology
Diet, High-Fat
Fatty Acids
/ metabolism
Lipid Metabolism
/ drug effects
Liver
/ drug effects
Liver Cirrhosis, Experimental
/ etiology
Male
Marine Toxins
Microcystins
/ toxicity
Non-alcoholic Fatty Liver Disease
/ etiology
Rats, Sprague-Dawley
microcystin-LR
nonalcoholic steatohepatitis
sub-chronic toxicity
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
received:
13
06
2019
revised:
02
07
2019
accepted:
04
07
2019
entrez:
21
7
2019
pubmed:
22
7
2019
medline:
1
9
2020
Statut:
epublish
Résumé
Microcystin-LR (MCLR) is a hepatotoxic cyanotoxin reported to cause a phenotype similar to nonalcoholic steatohepatitis (NASH). NASH is a common progressive liver disease that advances in severity due to exogenous stressors such as poor diet and toxicant exposure. Our objective was to determine how sub-chronic MCLR toxicity affects preexisting diet-induced NASH. Sprague-Dawley rats were fed one of three diets for 10 weeks: control, methionine and choline deficient (MCD), or high fat/high cholesterol (HFHC). After six weeks of diet, animals received vehicle, 10 µg/kg, or 30 µg/kg MCLR via intraperitoneal injection every other day for the final 4 weeks. Incidence and severity scoring of histopathology endpoints suggested that MCLR toxicity drove NASH to a less fatty and more fibrotic state. In general, expression of genes involved in
Identifiants
pubmed: 31323923
pii: toxins11070398
doi: 10.3390/toxins11070398
pmc: PMC6669744
pii:
doi:
Substances chimiques
Fatty Acids
0
Marine Toxins
0
Microcystins
0
cyanoginosin LR
EQ8332842Y
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIEHS NIH HHS
ID : K99 ES024455
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES024455
Pays : United States
Organisme : NIH HHS
ID : K99/R00ES024455
Pays : United States
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