Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma.
PI3K/AKT pathway
TP53
clonality
endometrial carcinoma
epithelial-to-mesenchymal transition
gene expression
metaplastic carcinoma
miRNA expression
mutation
uterine carcinosarcoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
09 Jul 2019
09 Jul 2019
Historique:
received:
24
05
2019
revised:
28
06
2019
accepted:
02
07
2019
entrez:
21
7
2019
pubmed:
22
7
2019
medline:
22
7
2019
Statut:
epublish
Résumé
Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive, high-grade, metaplastic carcinoma. At the morphological level, intratumor heterogeneity in ECS is due to an admixture of epithelial (carcinoma) and mesenchymal (sarcoma) components that can include heterologous tissues, such as skeletal muscle, cartilage, or bone. Most ECSs belong to the copy-number high serous-like molecular subtype of endometrial carcinoma, characterized by the
Identifiants
pubmed: 31324031
pii: cancers11070964
doi: 10.3390/cancers11070964
pmc: PMC6678708
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PIE15/00050
Organisme : Instituto de Salud Carlos III
ID : PI16/00887
Organisme : Instituto de Salud Carlos III
ID : CB16/12/00316
Organisme : Instituto de Salud Carlos III
ID : CB16/12/00231
Organisme : Instituto de Salud Carlos III
ID : CB16/12/00361
Organisme : Fundación Científica Asociación Española Contra el Cáncer
ID : AIO-aecc 2016
Organisme : Fundación Científica Asociación Española Contra el Cáncer
ID : Grupos Coordinados Traslacionales aecc 2018
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