Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial.
Aged
Aged, 80 and over
Alzheimer Disease
/ prevention & control
Brain
/ diagnostic imaging
Cognitive Dysfunction
/ prevention & control
Exercise
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Negative Results
Positron-Emission Tomography
Preventive Health Services
/ methods
Program Evaluation
Risk
Time Factors
Cognitive impairment
Hippocampal loss
Intervention
Physical activity
White matter hyperintensity
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
02
01
2018
revised:
30
01
2019
accepted:
03
02
2019
pubmed:
22
7
2019
medline:
24
9
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss.
Identifiants
pubmed: 31324405
pii: S0197-4580(19)30155-1
doi: 10.1016/j.neurobiolaging.2019.02.030
pii:
doi:
Banques de données
ANZCTR
['ACTRN12611000612910']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
132-141Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.