Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium.
Journal
The Journal of general physiology
ISSN: 1540-7748
Titre abrégé: J Gen Physiol
Pays: United States
ID NLM: 2985110R
Informations de publication
Date de publication:
05 08 2019
05 08 2019
Historique:
received:
26
09
2018
revised:
10
05
2019
accepted:
17
06
2019
pubmed:
22
7
2019
medline:
20
8
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
Dendritic spines are small subcompartments that protrude from the dendrites of neurons and are important for signaling activity and synaptic communication. These subcompartments have been characterized to have different shapes. While it is known that these shapes are associated with spine function, the specific nature of these shape-function relationships is not well understood. In this work, we systematically investigated the relationship between the shape and size of both the spine head and spine apparatus, a specialized endoplasmic reticulum compartment within the spine head, in modulating rapid calcium dynamics using mathematical modeling. We developed a spatial multicompartment reaction-diffusion model of calcium dynamics in three dimensions with various flux sources, including N-methyl-D-aspartate receptors (NMDARs), voltage-sensitive calcium channels (VSCCs), and different ion pumps on the plasma membrane. Using this model, we make several important predictions. First, the volume to surface area ratio of the spine regulates calcium dynamics. Second, membrane fluxes impact calcium dynamics temporally and spatially in a nonlinear fashion. Finally, the spine apparatus can act as a physical buffer for calcium by acting as a sink and rescaling the calcium concentration. These predictions set the stage for future experimental investigations of calcium dynamics in dendritic spines.
Identifiants
pubmed: 31324651
pii: jgp.201812261
doi: 10.1085/jgp.201812261
pmc: PMC6683673
doi:
Substances chimiques
Calcium Channels
0
Receptors, N-Methyl-D-Aspartate
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1017-1034Subventions
Organisme : NIMH NIH HHS
ID : R01 MH115556
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB009380
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2019 Bell et al.
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