RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
Animals
Clonal Selection, Antigen-Mediated
Encephalomyelitis, Autoimmune, Experimental
/ chemically induced
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
/ immunology
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
/ immunology
Membrane Proteins
/ genetics
Mice
Mice, Knockout
Monomeric GTP-Binding Proteins
/ genetics
Myelin-Oligodendrocyte Glycoprotein
/ adverse effects
Receptors, Antigen, T-Cell, alpha-beta
/ immunology
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
07 10 2019
07 10 2019
Historique:
received:
17
10
2018
revised:
29
03
2019
accepted:
19
06
2019
pubmed:
22
7
2019
medline:
11
6
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the threshold for negative selection. Here we show that deletion of the GTPase RRAS2 results in exacerbated negative selection and above-normal expression of positive selection markers. Furthermore,
Identifiants
pubmed: 31324740
pii: jem.20181959
doi: 10.1084/jem.20181959
pmc: PMC6781009
doi:
Substances chimiques
Membrane Proteins
0
Mog protein, mouse
0
Myelin-Oligodendrocyte Glycoprotein
0
Receptors, Antigen, T-Cell, alpha-beta
0
Rras2 protein, mouse
EC 3.6.1
Monomeric GTP-Binding Proteins
EC 3.6.5.2
Banques de données
GENBANK
['C34557']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2427-2447Informations de copyright
© 2019 Martínez-Riaño et al.
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