Deciphering the Role of WNT Signaling in Metabolic Syndrome-Linked Alzheimer's Disease.
Alzheimer’s disease (AD)
Hypercoagulation
Inflammation
MetS
Wnt signaling
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
21
05
2019
accepted:
09
07
2019
pubmed:
22
7
2019
medline:
8
10
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
It has been well established in recent research that there is a strong correlation between metabolic syndrome (MetS) and Alzheimer's disease (AD). However, the knowledge of exact mechanistic behind this association remains elusive. It has been reported in recent studies that inflammation and hypercoagulation are pivotal to the pathophysiology of MetS-induced AD. It is rather captivating that aberrant Wnt signaling pathway has been found to be implicated in each of the four conditions, i.e., inflammation, hypercoagulation, MetS, and AD. Deregulation of Wnt signaling has been affiliated with numerous brain pathologies, including Alzheimer's disease and insulin resistance. In recent past, it has been proposed that the Wnt pathway can act as a central integrator of metabolic signals from peripheral organs to the brain, which would constitute a unique character for Wnt signaling in glucose metabolism. The review educates in what way distinct components of Wnt signaling impact effector mediators of inflammation, hypercoagulation, which in turn decelerate the progression of AD in MetS. Furthermore, components of Wnt signaling, namely, Wnt3a and GSK-3β, interlink MetS and AD. The review opines a contemporary hypothesis that Wnt signaling is implicated in the pathogenesis of MetS-induced AD via impacting inflammation and coagulation. Hence, targeting Wnt signaling could be a novel approach to halt the progression of MetS-linked AD.
Identifiants
pubmed: 31325024
doi: 10.1007/s12035-019-01700-y
pii: 10.1007/s12035-019-01700-y
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-314Références
Inflamm Res. 2004 Oct;53(10):528-33
pubmed: 15597147
Circ Res. 2008 Nov 21;103(11):1280-8
pubmed: 18948618
Antiviral Res. 2015 May;117:99-109
pubmed: 25746333
Science. 2010 Aug 13;329(5993):849-53
pubmed: 20705860
Blood. 2004 Dec 15;104(13):3878-85
pubmed: 15339848
J Cell Physiol. 2008 Oct;217(1):215-27
pubmed: 18521822
Int J Neurosci. 2014 Feb;124(2):75-81
pubmed: 23855502
Prog Mol Biol Transl Sci. 2017;146:243-258
pubmed: 28253987
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):229-34
pubmed: 12509515
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54
pubmed: 24706870
Mol Psychiatry. 2014 Jan;19(1):88-98
pubmed: 23164821
Front Neurosci. 2019 Feb 28;13:164
pubmed: 30872998
J Neurochem. 2010 Mar;112(6):1539-51
pubmed: 20050968
J Cell Sci. 2010 May 1;123(Pt 9):1588-99
pubmed: 20388731
Med Sci Monit. 2017 Dec 12;23:5885-5891
pubmed: 29229897
J Biol Chem. 2002 Feb 22;277(8):5977-81
pubmed: 11742004
Nat Rev Drug Discov. 2004 Jun;3(6):479-87
pubmed: 15173837
Horm Metab Res. 2009 Feb;41(2):159-63
pubmed: 19214925
J Clin Invest. 2003 Dec;112(12):1788-90
pubmed: 14679173
J Biol Chem. 2016 Dec 9;291(50):25950-25964
pubmed: 27703002
J Clin Invest. 2012 Feb;122(2):586-99
pubmed: 22251704
J Mol Cell Biol. 2014 Feb;6(1):64-74
pubmed: 24549157
Cell. 2009 Apr 3;137(1):47-59
pubmed: 19345186
Dev Cell. 2009 Jul;17(1):9-26
pubmed: 19619488
Cytokine. 2004 May 7;26(3):106-13
pubmed: 15135804
Clin Exp Pharmacol Physiol. 2018 Oct 5;:null
pubmed: 30290001
J Proteome Res. 2013 Jun 7;12(6):2654-65
pubmed: 23550703
J Neurochem. 2011 Feb;116(4):522-9
pubmed: 21138436
Science. 2000 Aug 11;289(5481):950-3
pubmed: 10937998
Front Pharmacol. 2018 Jan 30;9:23
pubmed: 29441016
Dev Biol. 1976 Feb;48(2):461-5
pubmed: 815114
Blood Adv. 2018 May 8;2(9):954-963
pubmed: 29700007
Sci Rep. 2012;2:693
pubmed: 23012647
Behav Brain Res. 2018 Feb 26;339:57-65
pubmed: 29158110
Dev Growth Differ. 2008 May;50(4):229-43
pubmed: 18366384
J Biol Chem. 2014 Dec 26;289(52):36179-93
pubmed: 25336659
Exp Cell Res. 2004 Jul 1;297(1):186-96
pubmed: 15194435
Nutr Res. 2019 Oct;70:18-25
pubmed: 30049588
Toxicology. 2014 Jun 5;320:74-82
pubmed: 24560772
Metabolism. 2018 Jan;78:155-166
pubmed: 28986164
Nat Rev Neurosci. 2005 May;6(5):351-62
pubmed: 15832199
N Engl J Med. 2001 Mar 8;344(10):699-709
pubmed: 11236773
PLoS One. 2014 Jul 30;9(7):e103351
pubmed: 25076422
J Biol Chem. 2011 Aug 19;286(33):29388-96
pubmed: 21700708
Nature. 2001 May 17;411(6835):321-5
pubmed: 11357136
J Mol Med (Berl). 2005 Jun;83(6):429-39
pubmed: 15759102
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14973-8
pubmed: 11752446
Stroke. 2012 Feb;43(2):514-23
pubmed: 22116809
Mol Psychiatry. 2003 Feb;8(2):195-208
pubmed: 12610652
J Neuroimmune Pharmacol. 2012 Dec;7(4):763-73
pubmed: 22415718
NPJ Precis Oncol. 2018 Feb 20;2(1):5
pubmed: 29872723
Cell Metab. 2013 Apr 2;17(4):491-506
pubmed: 23562075
Hum Mutat. 2013 Sep;34(9):1221-5
pubmed: 23703864
Neural Regen Res. 2018 Oct;13(10):1705-1710
pubmed: 30136680
Nat Neurosci. 2007 Nov;10(11):1407-13
pubmed: 17952067
Curr Diab Rep. 2014 Apr;14(4):476
pubmed: 24526623
J Biol Chem. 2005 Mar 25;280(12):11615-25
pubmed: 15659394
J Med Genet. 2006 Oct;43(10):798-803
pubmed: 16723389
J Neurochem. 2001 Sep;78(6):1219-32
pubmed: 11579131
Curr Opin Cell Biol. 2007 Dec;19(6):612-7
pubmed: 17997088
Gene. 2003 Jan 2;302(1-2):179-83
pubmed: 12527209
Circulation. 2004 Jun 8;109(22):2698-704
pubmed: 15184294
BMC Dev Biol. 2002 Jul 02;2:8
pubmed: 12095419
J Neurosci. 2014 Feb 5;34(6):2191-202
pubmed: 24501359
Cell Metab. 2013 Feb 5;17(2):197-209
pubmed: 23395167
Br J Haematol. 2000 Jul;110(1):130-4
pubmed: 10930989
J Immunol. 2008 Aug 1;181(3):2165-73
pubmed: 18641355
Front Cell Neurosci. 2013 Jun 26;7:100
pubmed: 23805076
Front Immunol. 2016 Sep 22;7:378
pubmed: 27713747
Mol Med Rep. 2018 Mar;17(3):4113-4119
pubmed: 29257340
Exp Cell Res. 2005 Jun 10;306(2):357-63
pubmed: 15925592
Mol Immunol. 2012 Aug;52(1):38-49
pubmed: 22580404
Science. 1996 May 17;272(5264):1023-6
pubmed: 8638126
Diabetologia. 2010 Dec;53(12):2600-10
pubmed: 20821187
J Neurosci. 2012 Jun 27;32(26):8845-54
pubmed: 22745485
Nature. 1999 Apr 1;398(6726):422-6
pubmed: 10201372
Hum Mol Genet. 2008 Mar 1;17(5):667-78
pubmed: 18029386
N Engl J Med. 1999 Aug 19;341(8):586-92
pubmed: 10451465
Br J Haematol. 2005 Nov;131(4):417-30
pubmed: 16281932
Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79
pubmed: 23151663
Front Cell Neurosci. 2013 Jun 25;7:97
pubmed: 23805073
J Biol Chem. 2000 Apr 14;275(15):10761-6
pubmed: 10753867
Front Neurosci. 2015 May 18;9:173
pubmed: 26041981
J Neurochem. 2004 May;89(3):537-52
pubmed: 15086511
J Endocrinol. 2003 May;177(2):249-59
pubmed: 12740013
Int J Obes (Lond). 2014 Aug;38(8):1044-52
pubmed: 24232498
Metab Brain Dis. 2019 Aug;34(4):957-965
pubmed: 30848470
Exp Neurol. 2010 Jun;223(2):401-9
pubmed: 19782075
J Immunol. 2006 Jan 15;176(2):1019-25
pubmed: 16393989
Cell Metab. 2014 Feb 4;19(2):209-20
pubmed: 24506864
Thromb Haemost. 2001 Aug;86(2):543-9
pubmed: 11522001
Synapse. 2017 Oct;71(10):e21990
pubmed: 28650104
J Cell Physiol. 2009 Dec;221(3):658-67
pubmed: 19711354
Metab Brain Dis. 2017 Jun;32(3):651-665
pubmed: 28361262
J Neurosci. 2012 Mar 7;32(10):3492-8
pubmed: 22399772
J Cereb Blood Flow Metab. 2014 Jun;34(6):945-55
pubmed: 24569689
Lab Invest. 2007 Jun;87(6):613-24
pubmed: 17384665
Exp Neurol. 2015 Jul;269:43-55
pubmed: 25857536
Nat Rev Neurosci. 2010 Feb;11(2):77-86
pubmed: 20010950
Curr Top Dev Biol. 2012;98:1-34
pubmed: 22305157
Trends Endocrinol Metab. 2009 Jan;20(1):16-24
pubmed: 19008118
FEBS Lett. 2000 Jul 21;477(3):208-12
pubmed: 10908722
Blood. 1996 Sep 15;88(6):2093-100
pubmed: 8822928
J Clin Invest. 1987 Mar;79(3):918-25
pubmed: 3102560
Arthritis Rheum. 2012 Aug;64(8):2589-600
pubmed: 22328140
Drug News Perspect. 2009 Dec;22(10):579-91
pubmed: 20140278
J Biol Chem. 2012 Jan 6;287(2):1335-44
pubmed: 22128165
J Biol Chem. 2012 Mar 2;287(10):7213-23
pubmed: 22232553
J Biol Chem. 2017 Aug 18;292(33):13688-13701
pubmed: 28522609
Science. 1998 Sep 4;281(5382):1509-12
pubmed: 9727977
Neurobiol Aging. 2015 Feb;36(2):608-17
pubmed: 25475538
Nat Immunol. 2005 Aug;6(8):777-84
pubmed: 16007092
Development. 2008 Jan;135(2):367-75
pubmed: 18077588
Science. 2002 May 31;296(5573):1644-6
pubmed: 12040179
Science. 2007 Mar 2;315(5816):1278-82
pubmed: 17332414
Science. 2007 Jun 15;316(5831):1619-22
pubmed: 17569865
Nature. 2000 Apr 6;404(6778):635-43
pubmed: 10766250
Nature. 2004 Aug 5;430(7000):631-9
pubmed: 15295589
Hepatology. 2013 Mar;57(3):1203-14
pubmed: 23081841
Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G129-37
pubmed: 15790758
Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):504-10
pubmed: 18174455
Biochem Soc Trans. 2010 Aug;38(4):967-72
pubmed: 20658986