Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies.
Aging
Caloric restriction
Frailty
Healthspan
Lifespan
Obesity
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
29
03
2019
revised:
03
06
2019
accepted:
16
07
2019
pubmed:
22
7
2019
medline:
29
8
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
The health benefits of chronic caloric restriction (CR) resulting in lifespan extension are well established in many species and has been recently demonstrated also in non-human primates, but its effects in humans remain to be proven on a long-term basis. CR might be a very efficient anti-aging strategy but its definition and limits must be well understood before envisaging to apply it to human. In this review, we first report and compare the recently issued CR studies in non-human primates and humans and then try to understand what an optimal caloric intake is. In a last part, we will discuss the pertinence of using CR as an anti-aging strategy with respect to the risks of frailty and obesity.
Identifiants
pubmed: 31325469
pii: S0278-5846(19)30270-2
doi: 10.1016/j.pnpbp.2019.109702
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109702Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.