Borderline Symptoms at Age 12 Signal Risk for Poor Outcomes During the Transition to Adulthood: Findings From a Genetically Sensitive Longitudinal Cohort Study.
adolescence
borderline
longitudinal
personality
twin
Journal
Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
05
03
2019
revised:
25
06
2019
accepted:
11
07
2019
pubmed:
22
7
2019
medline:
19
3
2021
entrez:
21
7
2019
Statut:
ppublish
Résumé
Borderline personality disorder in adolescence remains a controversial construct. We addressed concerns about the prognostic significance of adolescent borderline pathology by testing whether borderline symptoms at age 12 years predict functioning during the transition to adulthood, at age 18 years, in areas critical to life-course development. We studied members of the Environmental Risk (E-Risk) Longitudinal Twin Study, which tracks the development of a birth cohort of 2,232 British twin children. At age 12, study members' borderline symptoms were measured using mothers' reports. At age 18, study members' personality, psychopathology, functional outcomes, and experiences of victimization were measured using self-reports, coinformant reports, and official records. At age 18, study members who had more borderline symptoms at age 12 were more likely to have difficult personalities, to struggle with poor mental health, to experience poor functional outcomes, and to have become victims of violence. Reports of poor outcomes were corroborated by coinformants and official records. Borderline symptoms in study members at 12 years old predicted poor outcomes over and above other behavioral and emotional problems during adolescence. Twin analyses showed that borderline symptoms in 12-year-olds were influenced by familial risk, particularly genetic risk, which accounted for associations with most poor outcomes at age 18. Borderline symptoms in 12-year-olds signal risk for pervasive poor functioning during the transition to adulthood. This association is driven by genetic influences, suggesting that borderline symptoms and poor outcomes are manifestations of shared genetic risk.
Identifiants
pubmed: 31325594
pii: S0890-8567(19)30467-8
doi: 10.1016/j.jaac.2019.07.005
pmc: PMC6980181
mid: NIHMS1041257
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1165-1177.e2Subventions
Organisme : NICHD NIH HHS
ID : P2C HD065563
Pays : United States
Organisme : Medical Research Council
ID : MR/P005918/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD077482
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007376
Pays : United States
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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