Gasotransmitters in health and disease: a mitochondria-centered view.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
03
2019
revised:
28
06
2019
accepted:
01
07
2019
pubmed:
22
7
2019
medline:
26
5
2020
entrez:
21
7
2019
Statut:
ppublish
Résumé
Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitochondria are key organelles in energy production, formation of reactive oxygen species and apoptosis, they are important mediators in preserving health and disease. Preserving or restoring mitochondrial function by gasotransmitters may be beneficial, and mitigate pathogenetic processes. In this review we discuss the actions of gasotransmitters with focus on their role in mitochondrial function and their therapeutic potential.
Identifiants
pubmed: 31325730
pii: S1471-4892(19)30017-7
doi: 10.1016/j.coph.2019.07.001
pii:
doi:
Substances chimiques
Gasotransmitters
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-93Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.