Rebound nystagmus, a window into the oculomotor integrator.
Cerebellum
Drift
Gaze-evoked nystagmus
Journal
Progress in brain research
ISSN: 1875-7855
Titre abrégé: Prog Brain Res
Pays: Netherlands
ID NLM: 0376441
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
22
7
2019
pubmed:
22
7
2019
medline:
8
5
2020
Statut:
ppublish
Résumé
Rebound nystagmus, a common cerebellar sign, is a transient nystagmus that appears on returning to straight-ahead gaze after prolonged eccentric gaze. The slow phases of rebound nystagmus are in the direction of prior eccentric gaze. After eccentric gaze, healthy subjects also show rebound nystagmus when fixation is removed. Rebound nystagmus is thought to be related to the function of the oculomotor neural integrator-the circuit that ensures accurate gaze holding after any eye movement-but the exact mechanism of rebound nystagmus is unknown. Here, we combine experimental data with mathematical modeling to test several hypotheses for the generation of rebound nystagmus. We show that two mechanisms contribute, one relies on vision and the other does not. Future experiments must determine if (1) the non-visual mechanism is related to eye position or to eye velocity signals and (2) whether these signals are based on afferent (proprioception) or efferent (corollary) information.
Identifiants
pubmed: 31325980
pii: S0079-6123(19)30116-5
doi: 10.1016/bs.pbr.2019.04.040
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-209Subventions
Organisme : NEI NIH HHS
ID : K99 EY027846
Pays : United States
Organisme : NIDCD NIH HHS
ID : K23 DC013552
Pays : United States
Informations de copyright
© 2019 Elsevier B.V. All rights reserved.