Altered immune system in frailty: Genetics and diet may influence inflammation.
Frailty syndrome
Immune system
Inflamm aging
Nutrients
SNP
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
22
12
2018
revised:
11
07
2019
accepted:
15
07
2019
pubmed:
22
7
2019
medline:
1
5
2020
entrez:
22
7
2019
Statut:
ppublish
Résumé
Frailty is a complex geriatric syndrome associated with biological vulnerability to stressors and decreased physiological reserve. Its etiology and pathogenesis are not completely understood, although various causes and complex pathways have been proposed. Immune system alterations (immunosenescence and "InflammAging") have been suggested to contribute to frailty, but a precise causative role of such alterations remains to be determined. Genetic studies support the suggestion of immune system involvement in frailty: genetic variants in genes involved in immune system function have been associated with the syndrome. Interestingly, nutritional status, through its effects on cellular metabolism, may also influence the immune system, i.e. hormone and cytokine (mainly adipocytokine) levels, and immune cell populations and function, increasing inflammation and contributing to frailty. This review aims to discuss the role of immune system alterations in frailty, analyzing the role of genetic factors in frailty onset and the impact of diet on inflammation and, in turn, on frailty.
Identifiants
pubmed: 31326616
pii: S1568-1637(18)30342-8
doi: 10.1016/j.arr.2019.100935
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100935Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.