Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.
locus coeruleus (LC)
magnetic resonance imaging (MRI)
neurodegeneration
noradrenaline (NA) biomarker
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
22
02
2019
revised:
12
04
2019
accepted:
01
05
2019
pubmed:
22
7
2019
medline:
13
5
2020
entrez:
22
7
2019
Statut:
ppublish
Résumé
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer's disease, atypical neurodegenerative dementias and Parkinson's disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.
Identifiants
pubmed: 31327002
pii: 5536581
doi: 10.1093/brain/awz193
pmc: PMC6736046
doi:
Substances chimiques
Biomarkers
0
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2558-2571Subventions
Organisme : NIA NIH HHS
ID : K24 AG053435
Pays : United States
Organisme : Medical Research Council
ID : MR/P012698/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P01271X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R006504/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom
Informations de copyright
© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain.
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