CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.
Aging
Animals
Antigens, CD34
/ metabolism
Bone Marrow Cells
/ cytology
Cell Cycle Checkpoints
/ drug effects
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p21
/ metabolism
Cyclins
/ antagonists & inhibitors
Fluorouracil
/ pharmacology
Hematopoiesis
/ drug effects
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
/ cytology
Humans
Lipopolysaccharides
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
RNA Interference
RNA, Small Interfering
/ metabolism
CABLES1
cell cycle
hematopoietic niches
hematopoietic stem cell homeostasis
mesenchymal stromal cells
p21
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
received:
14
08
2018
revised:
14
06
2019
accepted:
17
06
2019
pubmed:
23
7
2019
medline:
24
4
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long-term hematopoietic homeostasis during stress and aging. Young mice lacking Cables1 displayed hyperproliferation of hematopoietic progenitor cells. This defect was cell intrinsic, since it was reproduced in BM transplantation assays using wild-type animals as recipients. Overexpression and short hairpin RNA-mediated depletion of CABLES1 protein resulted in p21
Identifiants
pubmed: 31327733
pii: S2213-6711(19)30228-0
doi: 10.1016/j.stemcr.2019.06.002
pmc: PMC6700604
pii:
doi:
Substances chimiques
Antigens, CD34
0
Cables1 protein, mouse
0
Cyclin-Dependent Kinase Inhibitor p21
0
Cyclins
0
Lipopolysaccharides
0
RNA, Small Interfering
0
Fluorouracil
U3P01618RT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
274-290Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Nat Cell Biol. 2007 Aug;9(8):883-92
pubmed: 17618275
Nat Cell Biol. 2004 May;6(5):436-42
pubmed: 15122268
Mol Pharmacol. 2017 Sep;92(3):240-245
pubmed: 28119482
Mol Reprod Dev. 2011 Jan;78(1):22-32
pubmed: 21268180
Sci Rep. 2016 Nov 25;6:37827
pubmed: 27886253
Oncogene. 2015 May 7;34(19):2538-45
pubmed: 24975575
Cancer Res. 2015 Jan 1;75(1):147-158
pubmed: 25361894
Cancer Biol Ther. 2013 Jul;14(7):672-8
pubmed: 23792637
Nat Med. 2000 Nov;6(11):1235-40
pubmed: 11062534
Int Immunol. 2002 Nov;14(11):1313-23
pubmed: 12407022
Cell Stem Cell. 2012 May 4;10(5):520-30
pubmed: 22560076
Cancer Res. 2004 Jan 1;64(1):202-8
pubmed: 14729625
Cell Cycle. 2007 Nov 1;6(21):2678-84
pubmed: 17912041
Stem Cells. 2007 Apr;25(4):836-43
pubmed: 17170062
Eur J Biochem. 2001 Dec;268(23):6076-82
pubmed: 11733001
Nat Biotechnol. 2009 Jan;27(1):84-90
pubmed: 19060879
J Exp Med. 2011 Dec 19;208(13):2691-703
pubmed: 22110168
J Exp Med. 2014 Feb 10;211(2):245-62
pubmed: 24493802
Oncotarget. 2016 Jul 22;8(33):54082-54095
pubmed: 28903325
Cell. 2005 Jul 1;121(7):1109-21
pubmed: 15989959
Ann N Y Acad Sci. 2015 Jan;1335:32-44
pubmed: 25573321
Blood. 2013 May 30;121(22):4463-72
pubmed: 23564910
Cancer Biol Ther. 2005 Jan;4(1):103-7
pubmed: 15662117
Am J Pathol. 2007 Nov;171(5):1509-19
pubmed: 17982127
J Biol Chem. 2002 Jan 25;277(4):2951-7
pubmed: 11706030
Blood. 2006 Mar 15;107(6):2243-51
pubmed: 16291599
Neuron. 2000 Jun;26(3):633-46
pubmed: 10896159
Blood. 2006 Feb 1;107(3):1200-6
pubmed: 16234365
Stem Cells. 2018 Oct;36(10):1617-1629
pubmed: 30004606
Blood. 1999 Mar 1;93(5):1511-23
pubmed: 10029579
Biochem Biophys Res Commun. 2003 Dec 12;312(2):520-9
pubmed: 14637168
Cell. 2008 Feb 22;132(4):631-44
pubmed: 18295580
Nature. 2006 Sep 28;443(7110):421-6
pubmed: 16957735
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9194-9
pubmed: 15967997
J Immunol. 1999 Mar 15;162(6):3342-9
pubmed: 10092788
Cell. 2016 Nov 17;167(5):1296-1309.e10
pubmed: 27839867
Mod Pathol. 2003 Sep;16(9):863-8
pubmed: 13679449
J Exp Med. 2010 Jun 7;207(6):1173-82
pubmed: 20421392
Cancer Res. 2001 Oct 1;61(19):7325-32
pubmed: 11585773
Nat Commun. 2016 Aug 18;7:12475
pubmed: 27534895
Science. 2000 Mar 10;287(5459):1804-8
pubmed: 10710306