Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis.

Aged Antirheumatic Agents / therapeutic use Arthritis, Rheumatoid / complications Biopsy Female Humans Iatrogenic Disease Lymphoproliferative Disorders / complications Methotrexate / therapeutic use Peptic Ulcer Perforation / etiology Tacrolimus / therapeutic use

gastric perforation iatrogenic immunodeficiency-associated lymphoproliferative disorder methotrexate rheumatoid arthritis tacrolimus

Journal

Internal medicine (Tokyo, Japan)

ISSN: 1349-7235

Titre abrégé: Intern Med

Pays: Japan

ID NLM: 9204241

Informations de publication

Date de publication:
15 Nov 2019

Historique:

pubmed: 23 7 2019

medline: 11 2 2020

entrez: 23 7 2019

Statut: ppublish

Résumé

A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment.

Identifiants

DOI: 10.2169/internalmedicine.2782-19 PMID: 31327821 PMC: PMC6911763

pubmed: 31327821

doi: 10.2169/internalmedicine.2782-19

pmc: PMC6911763

doi:

Substances chimiques

Antirheumatic Agents 0

Tacrolimus WM0HAQ4WNM

Methotrexate YL5FZ2Y5U1

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

3331-3336

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