Thyroid and renal function in cats following low-dose radioiodine (111Mbq) therapy.
Journal
The Journal of small animal practice
ISSN: 1748-5827
Titre abrégé: J Small Anim Pract
Pays: England
ID NLM: 0165053
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
26
12
2018
revised:
16
05
2019
accepted:
17
06
2019
pubmed:
23
7
2019
medline:
2
7
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
To describe the effect of low-dose (111MBq) radioiodine therapy on thyroid and renal function in hyperthyroid cats over a 12-month follow-up period. Client-owned hyperthyroid cats underwent low-dose radioiodine therapy and were followed-up for 12 months. Immediately before radioiodine treatment, and at 1, 6 and 12 months afterwards, total thyroxine, thyroid stimulating hormone, serum creatinine and glomerular filtration rate were measured. Fifteen of the 24 (63%) cats achieved euthyroidism following low-dose radioiodine treatment. The incidence of overt hypothyroidism was six of 24 (25%) cats. Of the six cats developing overt hypothyroidism, three had decreased renal function, with decreased glomerular filtration rate preceding azotaemia in two of these individuals. Transient overt or subclinical hypothyroidism before restoration of euthyroidism was not observed. Low-dose radioiodine is effective treatment for hyperthyroidism in most cats but overt hypothyroidism may develop in some. Concurrent early decline in renal function may only be detected by measuring glomerular filtration rate rather than serum creatinine in some cats. Monitoring following radioiodine treatment should include total thyroxine and thyroid stimulating hormone and measurement of glomerular filtration rate should be considered in non-azotaemic cats.
Substances chimiques
Iodine Radioisotopes
0
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
523-528Subventions
Organisme : Langford Vets Clinical Research Fund
Organisme : PetSavers
ID : 14.12
Organisme : PetSavers, Langford Vets Clinical Research Fund
Informations de copyright
© 2019 British Small Animal Veterinary Association.
Références
Aldridge, C. , Behrend, E. N. , Martin, L. G. , et al. (2015) Evaluation of thyroid-stimulating hormone, total thyroxine, and free thyroxine concentrations in hyperthyroid cats receiving methimazole treatment. Journal of Veterinary Internal Medicine 29, 862-868
Becker, T. J. , Graves, T. K. , Kruger, J. M. , et al. (2000) Effects of methimazole on renal function in cats with hyperthyroidism. Journal of the American Animal Hospital Association 36, 215-223
Boag, A. K. , Neiger, R. , Slater, L. , et al. (2007) Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine. The Veterinary Record 161, 711-715
Finch, N. (2014) Measurement of glomerular filtration rate in cats: methods and advantages over routine markers of renal function. Journal of Feline Medicine and Surgery 16, 736-748
Finch, N. C. , Syme, H. M. , Elliott, J. , et al. (2011) Glomerular filtration rate estimation by use of a correction formula for slope-intercept plasma iohexol clearance in cats. American Journal of Veterinary Research 72, 1652-1659
Finch, N. C. , Syme, H. M. & Elliott, J. (2016) Risk factors for development of chronic kidney disease in cats. Journal of Veterinary Internal Medicine 30, 602-610
Finch, N. C. , Syme, H. M. & Elliott, J. (2018) Repeated measurements of renal function in evaluating its decline in cats. Journal of Feline Medicine and Surgery 20, 1144-1148
Graves, T. K. , Olivier, N. B. , Nachreiner, R. F. , et al. (1994) Changes in renal function associated with treatment of hyperthyroidism in cats. American Journal of Veterinary Research 55, 1745-1749
Jepson, R. E. , Brodbelt, D. , Vallance, C. , et al. (2009) Evaluation of predictors of the development of azotemia in cats. Journal of Veterinary Internal Medicine 23, 806-813
Lucy, J. M. , Peterson, M. E. , Randolph, J. F. , et al. (2017) Efficacy of low-dose (2 millicurie) versus standard-dose (4 millicurie) radioiodine treatment for cats with mild-to-moderate hyperthyroidism. Journal of Veterinary Internal Medicine 31, 326-334
Mooney, C. T. (1994) Radioactive iodine therapy for feline hyperthyroidism: efficacy and administration routes. The Journal of Small Animal Practice 35, 289-294
Morré, W. A. , Panciera, D. L. , Daniel, G. B. , et al. (2018) Investigation of a novel variable dosing protocol for radioactive treatment of feline hyperthyroidism. Journal of Veterinary Internal Medicine 32, 1856-1863
Panciera, D. L. & Lefebvre, H. P. (2009) Effect of experimental hypothyroidism on glomerular filtration rate and plasma creatinine concentration in dogs. Journal of Veterinary Internal Medicine 23, 1045-1050
Peacey, S. R. , Kumar, S. , Wright, D. , et al. (2012) The follow-up of radioiodine-treated hyperthyroid patients: should thyroid function be monitored more frequently? Journal of Endocrinological Investigation 35, 82-86
Peremans, K. , Vandermeulen, E. , van Hoek, I. , et al. (2008) Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat. Journal of Feline Medicine and Surgery 10, 460-465
Petersen, M. E. & Rishniw, M. (2016) Hyperthyroid cats develop transient or persistent subclinical hypothyroidism with sucessful radioiodine treatment. Proceedings of the 26th ECVIM congress. September 8th-10th Goteburg, Sweden. Journal of Veterinary Internal Medicine 31, 222
Peterson, M. E. & Becker, D. V. (1995) Radioiodine treatmentof 524 cats with hyperthyroidism. Journal of the American Veterinary Medical Association 207, 1422-1428
Peterson, M. E. , Castillano, C. A. & Rishniw, M. (2016) Evaluation of body weight, body condition, and muscle condition in cats with hyperthyroidism. Journal of Veterinary Internal Medicine 30, 1780-1789
Riensche, M. R. , Graves, T. K. & Schaeffer, D. J. (2008) An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats. Journal of Feline Medicine and Surgery 10, 160-6
Slater, M. R. , Geller, S. & Rogers, K. (2001) Long-term health and predictors of survival for hyperthyroid cats treated with iodine 131. Journal of Veterinary Internal Medicine 15, 47-51
Stephens, M. J. , O'Neill, D. G. , Church, D. B. , McGreevy, P . D. , Thomson, P . C. & Brodbelt, D. C. (2014) Feline hyperthyroidism reported in primary-care veterinary practices in England: prevalence, associated factors and spatial distribution. Veterinary Record 175, 458
van Hoek, I. , Lefebvre, H. P. , Kooistra, H. S. , Croubels, S. , Binst, D. Peremans, K. & Daminet, S. (2008) Plasma clearance of exogenous creatinine, exo-iohexol, and endo-iohexol in hyperthyroid cats before and after treatment with radioiodine. Journal of Veterinary Internal Medicine 22, 879-85
Wakeling, J. , Moore, K. , Elliott, J. , et al. (2008) Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. The Journal of Small Animal Practice 49, 287-294
Wakeling, J. , Elliott, J. & Syme, H. (2011) Evaluation of predictors for the diagnosis of hyperthyroidism in cats. Journal of Veterinary Internal Medicine 25, 1057-1065
Williams, T. L. , Elliott, J. & Syme, H. M. (2010a) Association of iatrogenic hypothyroidism with azotemia and reduced survival time in cats treated for hyperthyroidism. Journal of Veterinary Internal Medicine 24, 1086-1092
Williams, T. L. , Peak, K. J. , Brodbelt, D. , et al. (2010b) Survival and the development of azotemia after treatment of hyperthyroid cats. Journal of Veterinary Internal Medicine 24, 863-869
Williams, T. L. , Elliott, J. & Syme, H. M. (2014) Effect on renal function of restoration of euthyroidism in hyperthyroid cats with iatrogenic hypothyroidism. Journal of Veterinary Internal Medicine 28, 1251-1255