Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study.
Aged
Alzheimer Disease
Amyloid beta-Peptides
/ metabolism
Brain
/ metabolism
Brain Ischemia
/ metabolism
Disease Progression
Educational Status
Female
Gyrus Cinguli
/ metabolism
Humans
Male
Middle Aged
Pilot Projects
Positron-Emission Tomography
/ methods
Regression Analysis
Risk Factors
Stroke
/ metabolism
11C-labeled Pittsburgh compound B
amyloid β deposition
education
follow-up study
positron emission tomography
stroke
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
14
02
2019
accepted:
17
07
2019
pubmed:
23
7
2019
medline:
9
4
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
A direct causal relationship of cerebrovascular risk factors/stroke to amyloid β (Aβ) deposition has yet to be shown. We conducted [ Patients were recruited 14 to 28 days after acute subcortical ischemic stroke and examined with [ Voxel-based analysis revealed a significant increase of [ Our results suggest that processes before and after the onset of ischemic stroke may trigger Aβ deposition in the PCu/PCC, whereby amyloid deposition begins at an early stage of Alzheimer's disease (AD). Our findings support the existence of a cooperative association between vascular risk factors/stroke and AD progression. Further, educational achievement had a protective effect against the increase in Aβ accumulation.
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1651-1657Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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