Testicular organoids to study cell-cell interactions in the mammalian testis.
cell-cell interaction
germ cell niche
morphogenesis
testicular organoids
Journal
Andrology
ISSN: 2047-2927
Titre abrégé: Andrology
Pays: England
ID NLM: 101585129
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
16
04
2019
revised:
03
06
2019
accepted:
19
06
2019
pubmed:
23
7
2019
medline:
22
5
2021
entrez:
23
7
2019
Statut:
ppublish
Résumé
Over the last ten years, three-dimensional organoid culture has garnered renewed interest, as organoids generated from primary cells or stem cells with cell associations and functions similar to organs in vivo can be a powerful tool to study tissue-specific cell-cell interactions in vitro. Very recently, a few interesting approaches have been put forth for generating testicular organoids for studying the germ cell niche microenvironment. To review different model systems that have been employed to study germ cell biology and testicular cell-cell interactions and discuss how the organoid approach can address some of the shortcomings of those systems. Testicular organoids that bear architectural and functional similarities to their in vivo counterparts are a powerful model system to study cell-cell interactions in the germ cell niche. Organoids enable studying samples in humans and other large animals where in vivo experiments are not possible, allow modeling of testicular disease and malignancies and may provide a platform to design more precise therapeutic interventions.
Sections du résumé
BACKGROUND
Over the last ten years, three-dimensional organoid culture has garnered renewed interest, as organoids generated from primary cells or stem cells with cell associations and functions similar to organs in vivo can be a powerful tool to study tissue-specific cell-cell interactions in vitro. Very recently, a few interesting approaches have been put forth for generating testicular organoids for studying the germ cell niche microenvironment.
AIM
To review different model systems that have been employed to study germ cell biology and testicular cell-cell interactions and discuss how the organoid approach can address some of the shortcomings of those systems.
RESULTS AND CONCLUSION
Testicular organoids that bear architectural and functional similarities to their in vivo counterparts are a powerful model system to study cell-cell interactions in the germ cell niche. Organoids enable studying samples in humans and other large animals where in vivo experiments are not possible, allow modeling of testicular disease and malignancies and may provide a platform to design more precise therapeutic interventions.
Identifiants
pubmed: 31328437
doi: 10.1111/andr.12680
pmc: PMC7786437
mid: NIHMS1037756
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
835-841Subventions
Organisme : NICHD NIH HHS
ID : R01 HD091068
Pays : United States
Organisme : NIH HHS
ID : R01 OD016575
Pays : United States
Organisme : ODCDC CDC HHS
ID : R01 OD016575
Pays : United States
Informations de copyright
© 2019 American Society of Andrology and European Academy of Andrology.
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