Synthesis and Bioactivities of New Membrane-Active Agents with Aromatic Linker: High Selectivity and Broad-Spectrum Antibacterial Activity.
Animals
Anti-Bacterial Agents
/ chemical synthesis
Bacteria
/ drug effects
Biofilms
/ drug effects
Disease Models, Animal
Drug Resistance, Bacterial
/ drug effects
Enterobacter aerogenes
/ drug effects
Enterobacteriaceae
/ drug effects
Enterococcus faecalis
/ drug effects
Escherichia coli
/ drug effects
HeLa Cells
Humans
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Mice
Microbial Sensitivity Tests
Molecular Structure
Staphylococcal Infections
/ drug therapy
Stenotrophomonas maltophilia
/ drug effects
antibiotics
broad-spectrum antibacterial activity
low toxicity
membrane-active agents
selectivity
structure−activity relationships
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
13 09 2019
13 09 2019
Historique:
pubmed:
23
7
2019
medline:
18
6
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
The worldwide emergence of microbial resistance to antibiotics constitutes an important and growing public health threat, and novel antibiotics are urgently needed. In this report, a series of symmetrical membrane-active agents linked by an aromatic nucleus were designed and synthesized. Some showed high antibacterial activity against clinical drug-resistant bacterial isolates including methicillin-resistant
Identifiants
pubmed: 31328496
doi: 10.1021/acsinfecdis.9b00078
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM