The Association between Prefrontal Cortex Activity and Turning Behavior in People with and without Freezing of Gait.
Freezing of Gait
Turning
Wearable Sensors
fNIRS
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
16
01
2019
revised:
08
07
2019
accepted:
12
07
2019
pubmed:
23
7
2019
medline:
25
9
2020
entrez:
23
7
2019
Statut:
ppublish
Résumé
Turning elicits Freezing of Gait (FoG) episodes in people with Parkinson's disease (PD) and is thought to require higher cortical control compared to straight ahead gait. Functional near infrared spectroscopy (fNIRS) has been used to examine prefrontal cortex (PFC) activity while walking, but the relationship between PFC activity and turn performance remains unclear. The aim of this pilot study was to examine PFC activity during turning in PD and healthy controls, and to investigate the association between PFC activity and turning. Thirty-two subjects, 15 freezers (PD + FoG) and 17 non-freezers (PD - FoG), and 8 controls were asked to perform a 2-min turning-in-place test under single-task (ST) and dual-task (DT) conditions. Each participant wore an fNIRS system to measure changes in oxyhemoglobin, as measure of PFC activity, and inertial sensors to quantify turning. Our results show a significant group (p = .050), task (p = .039), and interaction (p = .047) for the PFC activity during turning. Specifically, PD + FoG show higher PFC during turning compared to the other groups; PFC activity during DT is overall different compared to ST with an opposite trend in PD + FoG compared to controls and PD - FoG. In addition, higher PFC is associated with worse FoG in PD + FoG (r = 0.57, p = .048) and with lower number of turns in PD - FoG (r = -0.70, p = .002). The increased PFC activity in PD and the association between higher PFC activity and poorer turning performance may be a sign of poor movement automaticity in PD. Although further investigations are required, these pilot findings may guide development of personalized treatments to improve motor automaticity in PD.
Identifiants
pubmed: 31330231
pii: S0306-4522(19)30508-1
doi: 10.1016/j.neuroscience.2019.07.024
pmc: PMC7778469
mid: NIHMS1655599
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-176Subventions
Organisme : NICHD NIH HHS
ID : R00 HD078492
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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