Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer.
cancer genomics
cancer immunology
copy number
mutation burden
oncogenic pathways
patient stratification
patient-derived xenograft
prognosis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
19 Jul 2019
19 Jul 2019
Historique:
received:
29
06
2019
revised:
15
07
2019
accepted:
15
07
2019
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
25
7
2019
Statut:
epublish
Résumé
The burden of somatic mutations and neoantigens has been associated with improved survival in cancer treated with immunotherapies, especially non-small cell lung cancer (NSCLC). However, there is uncertainty about their effect on outcome in early-stage untreated cases. We posited that the burden of mutations in a specific set of genes may also contribute to the prognosis of early NSCLC patients. From a small cohort of 36 NSCLC cases, we were able to identify somatic mutations and copy number alterations in 865 genes that contributed to patient overall survival. Simply, the number of altered genes (NAG) among these 865 genes was associated with longer disease-free survival (hazard ratio (HR) = 0.153,
Identifiants
pubmed: 31330989
pii: cancers11071009
doi: 10.3390/cancers11071009
pmc: PMC6678704
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Institute for Health Research
ID : NIHR Sheffield Biomedical Research Centre
Organisme : Canadian Institutes of Health Research
ID : FDN-148395
Pays : Canada
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