Epidermal Growth Factor is Effective in the Treatment of Diabetic Foot Ulcers: Meta-Analysis and Systematic Review.
diabetic foot ulcer
diabetic mellitus
meta-analysis
placebo
recombinant human epidermal growth factor
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
19 07 2019
19 07 2019
Historique:
received:
28
06
2019
revised:
17
07
2019
accepted:
18
07
2019
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
25
12
2019
Statut:
epublish
Résumé
Diabetic foot ulcers (DFUs) are one the common complications of diabetes mellitus. Many trials were performed to evaluate the effect of recombinant human epidermal growth factor (rhEGF) in healing DFUs. This meta-analysis was performed to synthesize the evidence of rhEGF treatment in DFUs in comparison to placebo. Databases included for the search were PubMed, EMBASE, the Cochrane Library, Web of Science, EBSCOhost, ScienceDirect, and Scopus (up to January 2019). The outcome of interest was the complete healing rate of DFUs. We performed random effects meta-analysis stratified by the types of administration route (intralesional injection and topical apply) by calculating the odds ratios (OR) and 95% confidence interval (95% CI). A total of six studies involving 530 patients were eligible for analysis. The combined OR (intralesional injection and topical apply) was 4.005 (95% CI: (2.248; 7.135),
Identifiants
pubmed: 31331038
pii: ijerph16142584
doi: 10.3390/ijerph16142584
pmc: PMC6678975
pii:
doi:
Substances chimiques
Recombinant Proteins
0
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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