Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond.

Animals CD4-Positive T-Lymphocytes / immunology Celiac Disease / diagnosis Glutens / immunology Humans
Autoimmunity HLA T cells celiac disease diagnosis therapy

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
10 2019
Historique:
received: 29 03 2019
revised: 22 05 2019
accepted: 28 05 2019
pubmed: 25 7 2019
medline: 27 6 2020
entrez: 24 7 2019
Statut: ppublish

Résumé

Few therapeutic and diagnostic tools specifically aim at T cells in autoimmune disorders, but are T cells a narrow target in these diseases? Lessons may be learned from celiac disease (CeD), one of the few autoimmune disorders where the T cell driving antigens are known, i.e. dietary gluten proteins. T cell clonotypes specific to gluten are expanded, persist for decades and express a distinct phenotype in CeD patients. Cells with this phenotype are increased also in other autoimmune conditions. Accordingly, disease-specific CD4

Identifiants

DOI: 10.1016/j.molmed.2019.05.009 PMID: 31331739
pubmed: 31331739
pii: S1471-4914(19)30126-1
doi: 10.1016/j.molmed.2019.05.009
pii:
doi:

Substances chimiques

Glutens 8002-80-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

836-852

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Asbjørn Christophersen (A)

KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway.

Louise F Risnes (LF)

KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway.

Shiva Dahal-Koirala (S)

KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway.

Ludvig M Sollid (LM)

KG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway; Department of Immunology, University of Oslo, Oslo, Norway; Department of Immunology, Oslo University Hospital, Oslo, Norway. Electronic address: l.m.sollid@medisin.uio.no.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Therapeutic and Diagnostic Implications of T...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Therapeutic and Diagnostic Implications of T...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndromes de malabsorption › Maladie coeliaque › Therapeutic and Diagnostic Implications of T...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines de stockage des graines › Prolamines › Glutens › Therapeutic and Diagnostic Implications of T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Therapeutic and Diagnostic Implications of T...