Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex.
cortical layers
motor planning
posterior parietal cortex
tactile coding
whisker somatotopy
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
11 09 2019
11 09 2019
Historique:
received:
03
03
2019
revised:
24
06
2019
accepted:
07
07
2019
pubmed:
25
7
2019
medline:
26
6
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
The posterior parietal cortex (PPC) in rodents is reciprocally connected to primary somatosensory and vibrissal motor cortices. The PPC neuronal circuitry could thus encode and potentially integrate incoming somatosensory information and whisker motor output. However, the information encoded across PPC layers during refined sensorimotor behavior remains largely unknown. To uncover the sensorimotor features represented in PPC during voluntary whisking and object touch, we performed loose-patch single-unit recordings and extracellular recordings of ensemble activity, covering all layers of PPC in anesthetized and awake, behaving male rats. First, using single-cell receptive field mapping, we revealed the presence of coarse somatotopy along the mediolateral axis in PPC. Second, we found that spiking activity was modulated during exploratory whisking in layers 2-4 and layer 6, but not in layer 5 of awake, behaving rats. Population spiking activity preceded actual movement, and whisker trajectory endpoints could be decoded by population spiking, suggesting that PPC is involved in movement planning. Finally, population spiking activity further increased in response to active whisker touch but only in PPC layers 2-4. Thus, we find layer-specific processing, which emphasizes the computational role of PPC during whisker sensorimotor behavior.
Identifiants
pubmed: 31332000
pii: JNEUROSCI.0693-19.2019
doi: 10.1523/JNEUROSCI.0693-19.2019
pmc: PMC6759035
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7332-7343Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 the authors.
Références
J Neurophysiol. 2000 Jul;84(1):401-14
pubmed: 10899214
Nature. 2000 Jul 20;406(6793):302-6
pubmed: 10917531
Neuron. 2001 Oct 11;32(1):141-9
pubmed: 11604145
J Neurophysiol. 2004 Jul;92(1):600-8
pubmed: 15056678
J Neurophysiol. 2005 Apr;93(4):2294-301
pubmed: 15563552
Curr Opin Neurobiol. 2004 Dec;14(6):698-706
pubmed: 15582371
Neuron. 2006 Mar 2;49(5):747-56
pubmed: 16504949
PLoS Biol. 2006 May;4(5):e124
pubmed: 16605304
J Neurosci. 2007 Feb 21;27(8):1922-32
pubmed: 17314288
J Physiol. 2007 May 15;581(Pt 1):139-54
pubmed: 17317752
J Comp Neurol. 2007 May 20;502(3):339-57
pubmed: 17366604
Biol Res. 2006;39(4):601-9
pubmed: 17657341
Cereb Cortex. 2008 May;18(5):979-89
pubmed: 17702950
Brain Res Rev. 2007 Oct;55(2):193-203
pubmed: 17822776
Neuron. 2007 Oct 25;56(2):339-55
pubmed: 17964250
Neuron. 2007 Nov 8;56(3):552-9
pubmed: 17988637
J Neurophysiol. 2008 Aug;100(2):740-52
pubmed: 18436634
Neurobiol Learn Mem. 2009 Feb;91(2):114-20
pubmed: 18675370
Nature. 2009 Feb 26;457(7233):1142-5
pubmed: 19151697
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16446-50
pubmed: 19805318
Cereb Cortex. 2010 Oct;20(10):2265-76
pubmed: 20453248
J Comp Neurol. 2011 Feb 15;519(3):405-19
pubmed: 21192075
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4188-93
pubmed: 21368112
Front Neuroanat. 2011 May 16;5:29
pubmed: 21647212
Brain Res. 1979 Jul 27;171(1):11-28
pubmed: 223730
Nature. 2012 Mar 14;484(7392):62-8
pubmed: 22419153
J Neurosci. 2012 Mar 28;32(13):4386-99
pubmed: 22457489
J Neurophysiol. 2012 Jul;108(2):697-707
pubmed: 22514297
PLoS Comput Biol. 2012;8(7):e1002591
pubmed: 22792058
Nat Neurosci. 2012 Oct;15(10):1365-7
pubmed: 22960933
Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17075-80
pubmed: 23027946
Prog Neurobiol. 2013 Apr;103:3-27
pubmed: 23195880
PLoS Comput Biol. 2012;8(12):e1002837
pubmed: 23284282
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:4279-82
pubmed: 23366873
J Comp Neurol. 1990 Jun 22;296(4):598-613
pubmed: 2358553
J Neurosci. 2013 Jun 5;33(23):9576-91
pubmed: 23739955
Nat Neurosci. 2013 Jul;16(7):824-31
pubmed: 23799475
Front Cell Neurosci. 2013 Jun 26;7:99
pubmed: 23805075
Neuron. 2013 Aug 7;79(3):579-93
pubmed: 23850594
J Neurosci. 1990 Aug;10(8):2638-48
pubmed: 2388081
Neuron. 2014 Jan 8;81(1):179-94
pubmed: 24361077
J Vis Exp. 2014 Feb 25;(84):e51359
pubmed: 24638127
Nat Rev Neurosci. 2014 May;15(5):313-25
pubmed: 24739786
Science. 2014 Apr 18;344(6181):319-24
pubmed: 24744380
Front Hum Neurosci. 2014 May 13;8:293
pubmed: 24860475
Curr Biol. 2014 Sep 22;24(18):R885-R897
pubmed: 25247368
Nature. 2015 Apr 9;520(7546):220-3
pubmed: 25600270
Front Neural Circuits. 2015 Jan 05;8:146
pubmed: 25601828
Nat Neurosci. 2015 Feb;18(2):170-81
pubmed: 25622573
Nature. 2015 Mar 5;519(7541):51-6
pubmed: 25731172
J Vis Exp. 2015 Apr 27;(98):null
pubmed: 25938559
Science. 2015 May 22;348(6237):906-10
pubmed: 25999506
PLoS Biol. 2015 Sep 22;13(9):e1002253
pubmed: 26393890
Cell Rep. 2015 Oct 27;13(4):647-656
pubmed: 26489463
Neuron. 2015 Dec 16;88(6):1253-1267
pubmed: 26671462
Front Behav Neurosci. 2016 Jan 05;9:356
pubmed: 26778990
J Comp Neurol. 2016 Dec 15;524(18):3774-3809
pubmed: 27126450
Elife. 2016 Aug 04;5:
pubmed: 27490481
Nat Neurosci. 2016 Aug 26;19(9):1165-74
pubmed: 27571195
Curr Opin Neurobiol. 2016 Oct;40:178-188
pubmed: 27632212
Elife. 2017 Jan 06;6:
pubmed: 28059700
J Neurosci. 2017 May 10;37(19):4954-4966
pubmed: 28408414
Curr Opin Neurobiol. 2017 Apr;43:177-186
pubmed: 28453975
Neuroscience. 2018 Jan 1;368:240-245
pubmed: 28642168
Curr Biol. 2017 Jul 24;27(14):R691-R695
pubmed: 28743011
Nat Rev Neurosci. 2017 Sep;18(9):530-546
pubmed: 28775344
Cell Rep. 2017 Sep 12;20(11):2575-2583
pubmed: 28903039
Neuron. 2017 Sep 13;95(6):1406-1419.e5
pubmed: 28910623
Nat Commun. 2017 Oct 11;8(1):870
pubmed: 29021587
Neuron. 2018 Jan 3;97(1):83-91.e5
pubmed: 29249287
Neuron. 2018 Feb 7;97(3):626-639.e8
pubmed: 29395913
Trends Neurosci. 2019 Jan;42(1):66-77
pubmed: 30201180
Nature. 2018 Nov;563(7729):79-84
pubmed: 30382200
Science. 2018 Nov 2;362(6414):584-589
pubmed: 30385578
Eur J Neurosci. 2019 May;49(10):1313-1329
pubmed: 30456892
Elife. 2018 Nov 23;7:
pubmed: 30468146
Neuron. 2019 Jan 2;101(1):76-90.e4
pubmed: 30472076
J Neurosci Methods. 1988 Aug;25(1):1-11
pubmed: 3146670
Behav Brain Res. 1987 Feb;23(2):127-45
pubmed: 3566907
Brain Res. 1970 Jan 20;17(2):205-42
pubmed: 4904874
Exp Brain Res. 1994;100(1):67-84
pubmed: 7813654
Exp Brain Res. 1994;101(1):24-34
pubmed: 7843299
Cereb Cortex. 1994 Jan-Feb;4(1):27-39
pubmed: 8180489
J Neurosci Methods. 1996 Apr;65(2):113-36
pubmed: 8740589
Annu Rev Neurosci. 1997;20:303-30
pubmed: 9056716
Philos Trans R Soc Lond B Biol Sci. 1997 Oct 29;352(1360):1421-8
pubmed: 9368930
J Neurosci. 1999 Jan 1;19(1):274-87
pubmed: 9870957