Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old.
CYP2B6 genotype
children
coinfection
human immunodeficiency virus
nevirapine
pharmacokinetics
tuberculosis
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
19
04
2019
accepted:
12
07
2019
pubmed:
25
7
2019
medline:
8
7
2020
entrez:
24
7
2019
Statut:
epublish
Résumé
Nevirapine-based antiretroviral therapy (ART) is one of the limited options in HIV-infected children younger than 3 years old (young children) with tuberculosis (TB) coinfection. To date, there are insufficient data to recommend nevirapine-based therapy during first-line antituberculosis (anti-TB) therapy in young children. We compared nevirapine pharmacokinetics (PK) in HIV-infected young children with and without TB coinfection. In the coinfected group, nevirapine PK was evaluated while on anti-TB therapy and after completing an anti-TB therapy regimen. Of 53 participants, 23 (43%) had TB-HIV coinfection. While the mean difference in nevirapine PK parameters between the two groups was not significant (
Identifiants
pubmed: 31332062
pii: AAC.00839-19
doi: 10.1128/AAC.00839-19
pmc: PMC6761507
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Antitubercular Agents
0
Nevirapine
99DK7FVK1H
Cytochrome P-450 CYP2B6
EC 1.14.14.1
Banques de données
ClinicalTrials.gov
['NCT01699633']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD071779
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068634
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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