Mosaic representations of odors in the input and output layers of the mouse olfactory bulb.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
14
03
2018
accepted:
30
05
2019
pubmed:
25
7
2019
medline:
5
11
2019
entrez:
24
7
2019
Statut:
ppublish
Résumé
The elementary stimulus features encoded by the olfactory system remain poorly understood. We examined the relationship between 1,666 physical-chemical descriptors of odors and the activity of olfactory bulb inputs and outputs in awake mice. Glomerular and mitral and tufted cell responses were sparse and locally heterogeneous, with only a weak dependence of their positions on physical-chemical properties. Odor features represented by ensembles of mitral and tufted cells were overlapping but distinct from those represented in glomeruli, which is consistent with an extensive interplay between feedforward and feedback inputs to the bulb. This reformatting was well described as a rotation in odor space. The physical-chemical descriptors accounted for a small fraction in response variance, and the similarity of odors in the physical-chemical space was a poor predictor of similarity in neuronal representations. Our results suggest that commonly used physical-chemical properties are not systematically represented in bulbar activity and encourage further searches for better descriptors of odor space.
Identifiants
pubmed: 31332371
doi: 10.1038/s41593-019-0442-z
pii: 10.1038/s41593-019-0442-z
pmc: PMC7370853
mid: NIHMS1063579
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1306-1317Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM065094
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014487
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017876
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS111673
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014366
Pays : United States
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