Ultrasound evaluation of varicoceles: guidelines and recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for detection, classification, and grading.


Journal

European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 19 02 2019
accepted: 20 05 2019
revised: 19 04 2019
pubmed: 25 7 2019
medline: 3 3 2020
entrez: 24 7 2019
Statut: ppublish

Résumé

Varicoceles are relatively common particularly in asymptomatic men and are even more prevalent in subfertile men, representing the most common potentially correctable cause of male infertility. Ultrasound (US) is the imaging modality of choice for varicocele evaluation, but there is no widely accepted consensus on examination technique, diagnostic criteria, or classification. In view of this uncertainty, the guideline writing group (WG) of the European Society of Urogenital Radiology (ESUR) Scrotal and Penile Imaging Working Group (ESUR-SPIWG) undertook a literature review and assessment of the quality of relevant evidence. The group then produced evidence-based recommendations for varicocele US examination, interpretation, and classification by consensus agreement. The results are presented in the form of 15 clinical questions with a brief summary of the relevant evidence and the authorised recommendations from the SPIWG. This paper provides a short summary of the evidence evaluation and the complete recommendations.Key Points• Varicocele is a common clinical problem; it is highly prevalent amongst subfertile men and the most common potentially correctable cause of male infertility. • Ultrasound is the imaging modality of choice for varicocele assessment, but there is no generally agreed consensus on the US examination technique or the criteria that should be used for diagnosis, grading, and classification. • This paper summarises the recommendations of the ESUR-SPIWG for standardising the US assessment of varicoceles. This includes examination technique, image interpretation, classification, and reporting.

Identifiants

pubmed: 31332561
doi: 10.1007/s00330-019-06280-y
pii: 10.1007/s00330-019-06280-y
doi:

Types de publication

Journal Article Practice Guideline

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-25

Références

Paick S, Choi WS (2019) Varicocele and testicular pain: a review. World J Mens Health 37(1):4–11
doi: 10.5534/wjmh.170010 pubmed: 29774668 pmcid: 29774668
Dubin L, Amelar RD (1970) Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril 21(8):606–609
doi: 10.1016/S0015-0282(16)37684-1 pubmed: 5433164 pmcid: 5433164
Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction and Urology (2014) Report on varicocele and infertility: a committee opinion. Fertil Steril 102(6):1556–1560
doi: 10.1016/j.fertnstert.2014.10.007
Khera M, Lipshultz LI (2008) Evolving approach to the varicocele. Urol Clin North Am 35(2):183–189
doi: 10.1016/j.ucl.2008.02.001 pubmed: 18423239 pmcid: 18423239
Zini A, Dohle G (2011) Are varicoceles associated with increased deoxyribonucleic acid fragmentation? Fertil Steril 96(6):1283–1287
doi: 10.1016/j.fertnstert.2011.10.016 pubmed: 22035729 pmcid: 22035729
Jungwirth A, Giwercman A, Tournaye H et al (2012) European Association of Urology guidelines on male infertility: the 2012 update. Eur Urol 62(2):324–332
doi: 10.1016/j.eururo.2012.04.048 pubmed: 22591628 pmcid: 22591628
Agarwal A, Deepinder F, Cocuzza M et al (2007) Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology. 70(3):532–538
doi: 10.1016/j.urology.2007.04.011 pubmed: 17905111 pmcid: 17905111
Brouwers MC, Kho ME, Browman GP et al (2010) AGREE II: advancing guideline development, reporting and evaluation in health care. CMAJ. 182(18):E839–E842
doi: 10.1503/cmaj.090449 pubmed: 20603348 pmcid: 20603348
van der Molen AJ, Reimer P, Dekkers IA et al (2018) Post-contrast acute kidney injury - Part 1: definition, clinical features, incidence, role of contrast medium and risk factors : recommendations for updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol 28(7):2845–2855
doi: 10.1007/s00330-017-5246-5 pubmed: 5986826 pmcid: 5986826
Guyatt GH, Oxman AD, Kunz R et al (2011) GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidemiol 64(4):395–400
doi: 10.1016/j.jclinepi.2010.09.012 pubmed: 21194891 pmcid: 21194891
Medicine OCfE-B. The Oxford 2011 Levels of Evidence 2011 Available from: https://www.cebm.net/2016/05/ocebm-levels-of-evidence/ . Accessed April 2019
Plus EE. GRADE: Grading of Recommendations Assessment, Development and Evaluation (A, B, C, D): John Wiley & Sons, Inc; 2018. Available from: http://www.essentialevidenceplus.com/product/concept_infomastery.cfm . Accessed April 2019
Dalkey N, Helmer O (1963) An experimental application of the DELPHI method to the use of experts. Manag Sci 9(3):458–467
doi: 10.1287/mnsc.9.3.458
Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H (2018) Guidelines on male infertility, European Association of Urology. EAU Guidelines Office, Arnhem. Available from: https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Male-Infertility-2018-large-text.pdf . Accessed April 2019
Saypol DC (1981) Varicocele. J Androl 2(2):61–71
doi: 10.1002/j.1939-4640.1981.tb00597.x
Alsaikhan B, Alrabeeah K, Delouya G, Zini A (2016) Epidemiology of varicocele. Asian J Androl 18(2):179–181
doi: 10.4103/1008-682X.172640 pubmed: 26763551 pmcid: 26763551
Dubin L, Amelar RD (1971) Etiologic factors in 1294 consecutive cases of male infertility. Fertil Steril 22(8):469–474
doi: 10.1016/S0015-0282(16)38400-X pubmed: 4398669 pmcid: 4398669
Kibar Y, Seckin B, Erduran D (2002) The effects of subinguinal varicocelectomy on Kruger morphology and semen parameters. J Urol 168(3):1071–1074
doi: 10.1016/S0022-5347(05)64577-6 pubmed: 12187225 pmcid: 12187225
Zini A, Boman JM (2009) Varicocele: red flag or red herring? Semin Reprod Med 27(2):171–178
doi: 10.1055/s-0029-1202306 pubmed: 19247919 pmcid: 19247919
Liguori G, Trombetta C, Garaffa G et al (2004) Color Doppler ultrasound investigation of varicocele. World J Urol 22(5):378–381
doi: 10.1007/s00345-004-0421-0 pubmed: 15322805 pmcid: 15322805
Marmar JL (2001) Varicocele and male infertility: Part II: the pathophysiology of varicoceles in the light of current molecular and genetic information. Hum Reprod Update 7(5):461–472
doi: 10.1093/humupd/7.5.461 pubmed: 11556493 pmcid: 11556493
Will MA, Swain J, Fode M, Sonksen J, Christman GM, Ohl D (2011) The great debate: varicocele treatment and impact on fertility. Fertil Steril 95(3):841–852
doi: 10.1016/j.fertnstert.2011.01.002 pubmed: 21272869 pmcid: 21272869
Naughton CK, Nangia AK, Agarwal A (2001) Varicocele and male infertility: Part II: pathophysiology of varicoceles in male infertility. Hum Reprod Update 7(5):473–481
doi: 10.1093/humupd/7.5.473 pubmed: 11556494 pmcid: 11556494
Papanikolaou F, Chow V, Jarvi K, Fong B, Ho M, Zini A (2000) Effect of adult microsurgical varicocelectomy on testicular volume. Urology. 56(1):136–139
doi: 10.1016/S0090-4295(00)00535-5 pubmed: 10869642 pmcid: 10869642
Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia. 39(6):203–215
doi: 10.1111/j.1439-0272.2007.00794.x pubmed: 18076419 pmcid: 18076419
Evers JH, Collins J, Clarke J (2008) Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev 2008(3):CD000479. https://doi.org/10.1002/14651858.CD000479.pub3
doi: 10.1002/14651858.CD000479.pub3
Kroese AC, De Lange NM, Collins JA, Evers JL (2013) Varicocele surgery, new evidence. Hum Reprod Update 19(4):317
doi: 10.1093/humupd/dmt004 pubmed: 23515200 pmcid: 23515200
Kroese ACJ, de Lange NM, Collins J, Evers JL (2012) Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst Rev (10):CD000479. https://doi.org/10.1002/14651858.CD000479.pub5
Smit M, Romijn JC, Wildhagen MF, Veldhoven JL, Weber RF, Dohle GR (2010) Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate. J Urol 183(1):270–274
doi: 10.1016/j.juro.2009.08.161 pubmed: 19913801 pmcid: 19913801
Baazeem A, Belzile E, Ciampi A et al (2011) Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol 60(4):796–808
doi: 10.1016/j.eururo.2011.06.018 pubmed: 21733620 pmcid: 21733620
Macleod R, Biyani CS, Cartledge J, Eardley I (2015) Varicocele. BMJ Clin Evid 2015
Kim KH, Lee JY, Kang DH, Lee H, Seo JT, Cho KS (2013) Impact of surgical varicocele repair on pregnancy rate in subfertile men with clinical varicocele and impaired semen quality: a meta-analysis of randomized clinical trials. Korean J Urol 54(10):703–709
doi: 10.4111/kju.2013.54.10.703 pubmed: 24175046 pmcid: 24175046
Fertility: assessment and treatment for people with fertility problems. National Institute for Health and Clinical Excellence: Guidance [CG11]. London (UK) 2004. www.nice.org.uk/guidance/cg11 . Accessed April 2019
Lotti F, Maggi M (2014) Ultrasound of the male genital tract in relation to male reproductive health. Hum Reprod Update 21(1):56–83
doi: 10.1093/humupd/dmu042 pubmed: 25038770 pmcid: 25038770
Hirsh AV, Cameron KM, Tyler JP, Simpson J, Pryor JP (1980) The Doppler assessment of varicoceles and internal spermatic vein reflux in infertile men. Br J Urol 52(1):50–56
doi: 10.1111/j.1464-410X.1980.tb02919.x pubmed: 7426951 pmcid: 7426951
Dhabuwala CB, Kumar AB, Kerkar PD, Bhutawala A, Pierce J (1989) Patterns of Doppler recordings and its relationship to varicocele in infertile men. Int J Androl 12(6):430–438
doi: 10.1111/j.1365-2605.1989.tb01333.x pubmed: 2696730 pmcid: 2696730
Sarteschi LM, Paoli R, Bianchini M, Menchini Fabris GF (1993) Lo studio del varicocele con eco-color-Doppler. G Ital Ultrasonologia 4(2):43–49
Hoekstra T, Witt MA (1995) The correlation of internal spermatic vein palpability with ultrasonographic diameter and reversal of venous flow. J Urol 153(1):82–84
doi: 10.1097/00005392-199501000-00029 pubmed: 7966798 pmcid: 7966798
Chiou RK, Anderson JC, Wobig RK et al (1997) Color Doppler ultrasound criteria to diagnose varicoceles: correlation of a new scoring system with physical examination. Urology. 50(6):953–956
doi: 10.1016/S0090-4295(97)00452-4 pubmed: 9426729 pmcid: 9426729
Cornud F, Belin X, Amar E, Delafontaine D, Helenon O, Moreau JF (1999) Varicocele: strategies in diagnosis and treatment. Eur Radiol 9(3):536–545
doi: 10.1007/s003300050706 pubmed: 10087130 pmcid: 10087130
Oyen RH (2002) Scrotal ultrasound. Eur Radiol 12(1):19–34
doi: 10.1007/s00330-001-1224-y pubmed: 11868071 pmcid: 11868071
Pauroso S, Di Leo N, Fulle I, Di Segni M, Alessi S, Maggini E (2011) Varicocele: ultrasonographic assessment in daily clinical practice. J Ultrasound 14(4):199–204
doi: 10.1016/j.jus.2011.08.001 pubmed: 23396816 pmcid: 23396816
Iosa G, Lazzarini D (2013) Hemodynamic classification of varicoceles in men: our experience. J Ultrasound 16(2):57–63
doi: 10.1007/s40477-013-0016-y pubmed: 24294344 pmcid: 24294344
Patil V, Shetty SC, Das SK (2016) Redefining the criteria for grading varicoceles based on reflux times: a clinicoradiological correlation. Ultrasound Q 32(1):82–85
doi: 10.1097/RUQ.0000000000000168 pubmed: 26938036 pmcid: 26938036
Wolverson MK, Houttuin E, Heiberg E, Sundaram M, Gregory J (1983) High-resolution real-time sonography of scrotal varicocele. AJR Am J Roentgenol 141(4):775–779
doi: 10.2214/ajr.141.4.775 pubmed: 6604430 pmcid: 6604430
Gonda RL Jr, Karo JJ, Forte RA, O'Donnell KT (1987) Diagnosis of subclinical varicocele in infertility. AJR Am J Roentgenol 148(1):71–75
doi: 10.2214/ajr.148.1.71 pubmed: 3024475 pmcid: 3024475
Orda R, Sayfan J, Manor H, Witz E, Sofer Y (1987) Diagnosis of varicocele and postoperative evaluation using inguinal ultrasonography. Ann Surg 206(1):99–101
doi: 10.1097/00000658-198707000-00015 pubmed: 3300579 pmcid: 3300579
McClure RD, Khoo D, Jarvi K, Hricak H (1991) Subclinical varicocele: the effectiveness of varicocelectomy. J Urol 145(4):789–791
doi: 10.1016/S0022-5347(17)38452-5 pubmed: 2005702 pmcid: 2005702
Eskew LA, Watson NE, Wolfman N, Bechtold R, Scharling E, Jarow JP (1993) Ultrasonographic diagnosis of varicoceles. Fertil Steril 60(4):693–697
doi: 10.1016/S0015-0282(16)56224-4 pubmed: 8405527 pmcid: 8405527
Pilatz A, Altinkilic B, Kohler E, Marconi M, Weidner W (2011) Color Doppler ultrasound imaging in varicoceles: is the venous diameter sufficient for predicting clinical and subclinical varicocele? World J Urol 29(5):645–650
doi: 10.1007/s00345-011-0701-4 pubmed: 21607575 pmcid: 21607575
Jarow JP, Ogle SR, Eskew LA (1996) Seminal improvement following repair of ultrasound detected subclinical varicoceles. J Urol 155(4):1287–1290
doi: 10.1016/S0022-5347(01)66245-1 pubmed: 8632555 pmcid: 8632555
Schiff JD, Li PS, Goldstein M (2006) Correlation of ultrasound-measured venous size and reversal of flow with Valsalva with improvement in semen-analysis parameters after varicocelectomy. Fertil Steril 86(1):250–252
doi: 10.1016/j.fertnstert.2005.12.038 pubmed: 16764870 pmcid: 16764870
Karami M, Mazdak H, Khanbabapour S, Adibi A, Nasr N (2014) Determination of the best position and site for color Doppler ultrasonographic evaluation of the testicular vein to define the clinical grades of varicocele ultrasonographically. Adv Biomed Res 3:17
doi: 10.4103/2277-9175.139192 pubmed: 24592367 pmcid: 24592367
Kim YS, Kim SK, Cho IC, Min SK (2015) Efficacy of scrotal Doppler ultrasonography with the Valsalva maneuver, standing position, and resting-Valsalva ratio for varicocele diagnosis. Korean J Urol 56(2):144–149
doi: 10.4111/kju.2015.56.2.144 pubmed: 25685302 pmcid: 25685302
Cina A, Minnetti M, Pirronti T et al (2006) Sonographic quantitative evaluation of scrotal veins in healthy subjects: normative values and implications for the diagnosis of varicocele. Eur Urol 50(2):345–350
doi: 10.1016/j.eururo.2006.02.055 pubmed: 16542771 pmcid: 16542771
Metin A, Bulut O, Temizkan M (1991) Relationship between the left spermatic vein diameter measured by ultrasound and palpated varicocele and Doppler ultrasound findings. Int Urol Nephrol 23(1):65–68
doi: 10.1007/BF02549730 pubmed: 1938219 pmcid: 1938219
Zampieri N, Cervellione RM (2008) Varicocele in adolescents: a 6-year longitudinal and followup observational study. J Urol 180(4):1653–1656
doi: 10.1016/j.juro.2008.03.114 pubmed: 18715592 pmcid: 18715592
Zhou T, Zhang W, Chen Q et al (2015) Effect of varicocelectomy on testis volume and semen parameters in adolescents: a meta-analysis. Asian J Androl 17(6):1012–1016
doi: 10.4103/1008-682X.148075 pubmed: 25677136 pmcid: 25677136
Sakamoto H, Saito K, Ogawa Y, Yoshida H (2008) Effects of varicocele repair in adults on ultrasonographically determined testicular volume and on semen profile. Urology. 71(3):485–489
doi: 10.1016/j.urology.2007.11.040 pubmed: 18342193 pmcid: 18342193
Cornud F, Amar E, Hamida K, Thiounn N, Helenon O, Moreau JF (2000) Imaging in male hypofertility and impotence. BJU Int 86:153–163
doi: 10.1046/j.1464-410X.2000.00593.x pubmed: 10961285 pmcid: 10961285
Goede J, Hack WW, Sijstermans K et al (2011) Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence. Horm Res Paediatr 76(1):56–64
doi: 10.1159/000326057 pubmed: 21464560 pmcid: 21464560
Kim ED, Lipshultz LI (1996) Role of ultrasound in the assessment of male infertility. J Clin Ultrasound 24(8):437–453
doi: 10.1002/(SICI)1097-0096(199610)24:8<437::AID-JCU4>3.0.CO;2-L pubmed: 8884521 pmcid: 8884521
Condorelli R, Calogero AE, La Vignera S (2013) Relationship between testicular volume and conventional or nonconventional sperm parameters. Int J Endocrinol 2013:6
doi: 10.1155/2013/145792
Tijani KH, Oyende BO, Awosanya GO, Ojewola RW, Yusuf AO (2014) Assessment of testicular volume: a comparison of fertile and sub-fertile West African men. Afr J Urol 20(3):136–140
doi: 10.1016/j.afju.2014.05.001
Sakamoto H, Ogawa Y, Yoshida H (2008) Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility. Asian J Androl 10(2):319–324
doi: 10.1111/j.1745-7262.2008.00340.x pubmed: 18097521 pmcid: 18097521
Sakamoto H, Yajima T, Nagata M, Okumura T, Suzuki K, Ogawa Y (2008) Relationship between testicular size by ultrasonography and testicular function: measurement of testicular length, width, and depth in patients with infertility. Int J Urol 15(6):529–533
doi: 10.1111/j.1442-2042.2008.02071.x pubmed: 18430152 pmcid: 18430152
Lambert B (1951) The frequency of mumps and of mumps orchitis and the consequences for sexuality and fertility. Acta Genet Stat Med 2(Suppl. 1:1–166
pubmed: 15444009 pmcid: 15444009
Mbaeri TU, Orakwe JC, Nwofor AME, Oranusi CK, Mbonu OO (2013) Ultrasound measurements of testicular volume: comparing the three common formulas with the true testicular volume determined by water displacement. Afr J Urol 19(2):69–73
doi: 10.1016/j.afju.2012.11.004
Sakamoto H, Saito K, Oohta M, Inoue K, Ogawa Y, Yoshida H (2007) Testicular volume measurement: comparison of ultrasonography, orchidometry, and water displacement. Urology. 69(1):152–157
doi: 10.1016/j.urology.2006.09.012 pubmed: 17270639 pmcid: 17270639
Liguori G, Trombetta C, Ollandini G et al (2009) Predictive factors of better improvement in semen quality after sclerotization of varicocele: preliminary report. J Androl Sci 16:47–53
Abdel-Meguid TA, Al-Sayyad A, Tayib A, Farsi HM (2011) Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial. Eur Urol 59(3):455–461
doi: 10.1016/j.eururo.2010.12.008 pubmed: 21196073 pmcid: 21196073
Liguori G, Ollandini G, Pomara G et al (2010) Role of renospermatic basal reflow and age on semen quality improvement after sclerotization of varicocele. Urology. 75(5):1074–1078
doi: 10.1016/j.urology.2009.10.068 pubmed: 20149422 pmcid: 20149422
Cornud F, Amar E, Hamida K, Helenon O, Moreau JF (2001) Ultrasound findings in male hypofertility and impotence. Eur Radiol 11(11):2126–2136
doi: 10.1007/s003300101125 pubmed: 11702152 pmcid: 11702152
Kocakoc E, Serhatlioglu S, Kiris A, Bozgeyik Z, Ozdemir H, Bodakci MN (2003) Color Doppler sonographic evaluation of inter-relations between diameter, reflux and flow volume of testicular veins in varicocele. Eur Radiol 47(3):251–256
doi: 10.1016/S0720-048X(02)00182-1
Kozakowski KA, Gjertson CK, Decastro GJ, Poon S, Gasalberti A, Glassberg KI (2009) Peak retrograde flow: a novel predictor of persistent, progressive and new onset asymmetry in adolescent varicocele. J Urol 181(6):2717–2722
doi: 10.1016/j.juro.2009.02.038 pubmed: 19375756 pmcid: 19375756
Tasci AI, Resim S, Caskurlu T, Dincel C, Bayraktar Z, Gurbuz G (2001) Color Doppler ultrasonography and spectral analysis of venous flow in diagnosis of varicocele. Eur Urol 39(3):316–321
doi: 10.1159/000052460 pubmed: 11275726 pmcid: 11275726
Mohseni MJ, Nazari H, Amini E et al (2011) Shunt-type and stop-type varicocele in adolescents: prognostic value of these two different hemodynamic patterns. Fertil Steril 96(5):1091–1096
doi: 10.1016/j.fertnstert.2011.08.024 pubmed: 21924715 pmcid: 21924715
Glassberg KI (2014) My indications for treatment of the adolescent varicocele (and why?). Trans Androl Urol 3(4):402–412
Paduch DA, Niedzielski J (1997) Repair versus observation in adolescent varicocele: a prospective study. J Urol 158(3):1128–1132
doi: 10.1016/S0022-5347(01)64403-3 pubmed: 9258155 pmcid: 9258155
Poon SA, Gjertson CK, Mercado MA, Raimondi PM, Kozakowski KA, Glassberg KI (2010) Testicular asymmetry and adolescent varicoceles managed expectantly. J Urol 183(2):731–734
doi: 10.1016/j.juro.2009.10.028 pubmed: 20022048 pmcid: 20022048
Morteza T, Ehsan A (2016) Quantitative Doppler assessment of flow characteristics in pampiniform venous plexus, in patients with varicocele: is there any relationship with semen analysis? PJR. 20(3):121–124
Van Batavia JP, Badalato G, Fast A, Glassberg KI (2013) Adolescent varicocele-is the 20/38 harbinger a durable predictor of testicular asymmetry? J Urol 189(5):1897–1902
doi: 10.1016/j.juro.2012.11.011 pubmed: 23154205 pmcid: 23154205
Hsu HS, Chang LS, Cheng MT, Wei YH (1994) Decreased blood flow and defective energy metabolism in the varicocele-bearing testicles of rats. Eur Urol 25:71–75
doi: 10.1159/000475250 pubmed: 8307080 pmcid: 8307080
Zhang M, Du L, Liu Z, Qi H, Chu Q (2014) The effects of varicocelectomy on testicular arterial blood flow: laparoscopic surgery versus microsurgery. Urol J 11(5):1900–1906
pubmed: 25361712 pmcid: 25361712
Grasso FL, Pepe P, Panella P, Pepe F (1997) Volocimetric evaluation of spermatic vessels with echo color Doppler in patients with idiopathic varicocele. Minerva Urol Nefrol 49(4):179–182
Ross JA, Watson JN Jr, Jarow JP (1994) The effect of varicoceles on testicular blood flow in man. Urology. 44(4):535–539
doi: 10.1016/S0090-4295(94)80053-7 pubmed: 7941192 pmcid: 7941192
Akcar N, Turgut M, Adapinar B, Ozkan IR (2004) Intratesticular arterial resistance and testicular volume in infertile men with subclinical varicocele. J Clin Ultrasound 32(8):389–393
doi: 10.1002/jcu.20059 pubmed: 15372446 pmcid: 15372446
Tarhan S, Gumus B, Gunduz I, Ayyildiz V, Goktan C (2003) Effect of varicocele on testicular artery blood flow in men color Doppler investigation. Scand J Urol Nephrol 37(1):38–42
doi: 10.1080/00365590310008677 pubmed: 12745742 pmcid: 12745742
Biagiotti G, Cavallini G, Modenini F, Vitali G, Gianaroli L (2002) Spermatogenesis and spectral echo-colour Doppler traces from the main testicular artery. BJU Int 90(9):903–908
doi: 10.1046/j.1464-410X.2002.03033.x pubmed: 12460354 pmcid: 12460354
Unsal A, Turgut AT, Taskin F, Kosar U, Karaman CZ (2007) Resistance and pulsatility index increase in capsular branches of testicular artery: indicator of impaired testicular microcirculation in varicocele? J Clin Ultrasound 35(4):191–195
doi: 10.1002/jcu.20331 pubmed: 17366558 pmcid: 17366558
Baigorri BF, Dixon RG (2016) Varicocele: a review. Semin Intervent Radiol 33(3):170–176
doi: 10.1055/s-0036-1586147 pubmed: 27582603 pmcid: 27582603
(1985) Comparison among different methods for the diagnosis of varicocele. World Health Organisation.. Fertil Steril 43(4):575–582
Cariati M, Pieri S, Agresti P et al (2012) Diagnosis of right-sided varicocele: a retrospective comparative study between clinical examination, Doppler findings, US imaging and vascular anatomy at phlebography. Eur J Radiol 81(9):1998–2006
doi: 10.1016/j.ejrad.2011.05.015 pubmed: 21664780 pmcid: 21664780
DeCastro GJ, Shabsigh A, Poon SA, Laor L, Glassberg KI (2009) Adolescent varicocelectomy - is the potential for catch-up growth related to age and/or Tanner stage? J Urol 181(1):322–327
doi: 10.1016/j.juro.2008.09.037 pubmed: 19013614 pmcid: 19013614
Gat Y, Bachar GN, Zukerman Z, Belenky A, Gorenish M (2004) Physical examination may miss the diagnosis of bilateral varicocele: a comparative study of 4 diagnostic modalities. J Urol 172(4):1414–1417
doi: 10.1097/01.ju.0000138540.57137.5f pubmed: 15371858 pmcid: 15371858
Pfeiffer D, Berger J, Schoop C, Tauber R (2006) A Doppler-based study on the prevalence of varicocele in German children and adolescents. Andrologia. 38(1):13–19
doi: 10.1111/j.1439-0272.2006.00680.x pubmed: 16420237 pmcid: 16420237
Preziosi P, Miano R, Bitelli M, Ciolfi MG, Micali S, Micali F (2001) Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. J Endourol 15(10):1001–1003
doi: 10.1089/089277901317203092 pubmed: 11789975 pmcid: 11789975
Ding H, Tian J, Du W, Zhang L, Wang H, Wang Z (2012) Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials. BJU Int 110(10):1536–1542
doi: 10.1111/j.1464-410X.2012.11093.x pubmed: 22642226 pmcid: 22642226
Cervellione RM, Corroppolo M, Bianchi A (2008) Subclinical varicocele in the pediatric age group. J Urol 179(2):717–719
doi: 10.1016/j.juro.2007.09.095 pubmed: 18082829 pmcid: 18082829
Zampieri N, Dall’Agnola A (2011) Subclinical varicocele and sports: a longitudinal study. Urology. 77(5):1199–1202
doi: 10.1016/j.urology.2010.09.057 pubmed: 21195464 pmcid: 21195464
Diamond DA (2007) Adolescent varicocele. Curr Opin Urol 17(4):263–267
doi: 10.1097/MOU.0b013e3281ddb30c pubmed: 17558270 pmcid: 17558270
Cvitanic OA, Cronan JJ, Sigman M, Landau ST (1993) Varicoceles: postoperative prevalence-a prospective study with color Doppler US. Radiology. 187(3):711–714
doi: 10.1148/radiology.187.3.8497618 pubmed: 8497618 pmcid: 8497618
Rotker K, Sigman M (2016) Recurrent varicocele. Asian J Androl 18(2):229–233
doi: 10.4103/1008-682X.171578 pubmed: 26806078 pmcid: 26806078
Glassberg KI, Badalato GM, Poon SA, Mercado MA, Raimondi PM, Gasalberti A (2011) Evaluation and management of the persistent/recurrent varicocele. Urology. 77(5):1194–1198
doi: 10.1016/j.urology.2010.10.013 pubmed: 21256543 pmcid: 21256543
Kwak N, Siegel D (2014) Imaging and interventional therapy for varicoceles. Curr Urol Rep 15(4):399
El-Haggar S, Nassef S, Gadalla A, Latif A, Mostafa T (2012) Ultrasonographic parameters of the spermatic veins at the inguinal and scrotal levels in varicocele diagnosis and post-operative repair. Andrologia. 44(3):210–213
doi: 10.1111/j.1439-0272.2011.01207.x pubmed: 22175528 pmcid: 22175528
Winkelbauer FW, Ammann ME, Karnel F, Lammer J (1994) Doppler sonography of varicocele: long-term follow-up after venography and transcatheter sclerotherapy. J Ultrasound Med 13(12):953–958
doi: 10.7863/jum.1994.13.12.953 pubmed: 7877206 pmcid: 7877206
Palazzo S, Boezio F, Mancini V et al (2002) Significance of scrotal Doppler color ultrasonography in the postoperative control of patients treated with varicocelectomy. Arch Ital Urol Androl 74(4):247–249
pubmed: 12508740 pmcid: 12508740
Hauser R, Yogev L, Greif M et al (1997) Sperm binding and ultrasound changes after operative repair of varicocele: correlation with fecundity. Andrologia. 29(3):145–147
doi: 10.1111/j.1439-0272.1997.tb00309.x pubmed: 9197919 pmcid: 9197919
Zucchi A, Mearini L, Mearini E, Fioretti F, Bini V, Porena M (2006) Varicocele and fertility: relationship between testicular volume and seminal parameters before and after treatment. J Androl 27(4):548–551
doi: 10.2164/jandrol.05200 pubmed: 16598029 pmcid: 16598029
Trombetta C, Salisci E, Deriu M et al (1993) Echo-flowmetric control 6 years after percutaneous treatment of varicocele. Arch Ital Urol Androl 65(4):363–367
pubmed: 8353541 pmcid: 8353541
Haller J, Gritzmann N, Czembirek H et al (1986) Pulsed duplex sonographic follow-up of varicoceles following sclerotherapy. Rofo. 145(5):547–550
doi: 10.1055/s-2008-1048986 pubmed: 3024251 pmcid: 3024251
Hamm B, Sorensen R, Berger T (1986) Non-invasive imaging procedures in the diagnosis and control of therapy of varicoceles. 2. Importance of thermography and sonography for therapy control following sclerotherapy of varicoceles. Rofo. 144(6):665–669
doi: 10.1055/s-2008-1048859 pubmed: 3012701 pmcid: 3012701
Mastrojeni C, Pagano G, Scalisi M, Leonello G, Manfré A, Versaci A (2001) Idiopathic varicocele. Diagnosis and follow-up with CW-Doppler and echo-color-Doppler: our experience. G Chir. 22(1-2):41–44
Cil AS, Bozkurt M, Bozkurt DK, Gok M (2015) Investigating the relationship between persistent reflux flow on the first postoperative day and recurrent varicocele in varicocelectomy patients. J Clin Med Res 7(1):29–32
doi: 10.14740/jocmr1967w pubmed: 25368698 pmcid: 25368698
El-Saeity NS, Sidhu PS (2006) “Scrotal varicocele, exclude a renal tumour”. Is this evidence based? Clin Radiol 61(7):593–599
doi: 10.1016/j.crad.2006.02.011 pubmed: 16784945 pmcid: 16784945
Spittel JA Jr, DeWeerd JH, Shick RM (1959) Acute varicocele: a vascular clue to renal tumor. Proc Staff Meet Mayo Clin 34(5):134–137
pubmed: 13658245 pmcid: 13658245
Gibbons RP, Monte JE, Correa RJ Jr, Mason JT (1976) Manifestations of renal cell carcinoma. Urology. 8(3):201–206
doi: 10.1016/0090-4295(76)90366-6 pubmed: 788291 pmcid: 788291
Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF (1971) Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases. Cancer. 28(5):1165–1177
doi: 10.1002/1097-0142(1971)28:5<1165::AID-CNCR2820280513>3.0.CO;2-G pubmed: 5125665 pmcid: 5125665
El Abiad Y, Qarro A (2016) Acute varicocele revealing renal cancer. N Engl J Med 374(21):2075
doi: 10.1056/NEJMicm1506668 pubmed: 27223149 pmcid: 27223149
Bate J (1927) Symptomatic varicocele. J Urol 18(6):649–662
doi: 10.1016/S0022-5347(17)73317-4
Ding GX, Song NH, Feng CC et al (2012) Is there an association between advanced stage of renal cell carcinoma and paraneoplastic syndrome? Med Princ Pract 21(4):370–374
doi: 10.1159/000334873 pubmed: 22237047 pmcid: 22237047
Ates N, Yuksel M, Ylmaz S, Habibi M, Ipekci T (2016) Retroperitoneal paraganglioma presenting as right-sided varicocele: case report. Ann Saudi Med 36(2):148–151
doi: 10.5144/0256-4947.2016.21.3.1135 pubmed: 26997533 pmcid: 26997533
Arrabal-Polo MA, Merino-Salas S (2013) Acute left varicocele in an adult. CMAJ. 185(4):323
doi: 10.1503/cmaj.121253 pubmed: 23382262 pmcid: 23382262
Chandramohan S, Chakravertry S (2007) Re: “Scrotal varicocoele, exclude a renal tumour”. Is this evidence based? Clin Radiol 62(2):192–193
doi: 10.1016/j.crad.2006.09.021 pubmed: 17207706 pmcid: 17207706
Espinosa Bravo R, Lemourt Oliva M, Pérez Monzón AF et al (2003) Carcinoma de células renales y varicocele izquierdo de forma simultánea. Arch Esp Urol 56(5):533–535
pubmed: 12918314 pmcid: 12918314
Robson J, Wolstenhulme S, Knapp P (2012) Is there a co-association between renal or retroperitoneal tumours and scrotal varicoceles? A systematic review. Ultrasound. 20(4):182–191
doi: 10.1258/ult.2012.012020
Oster J (1971) Varicocele in children and adolescents: an investigation of the incidence among Danish school children. Scand J Urol Nephrol 5(1):27–32
doi: 10.3109/00365597109133569 pubmed: 5093090 pmcid: 5093090
Akbay E, Cayan S, Doruk E, Duce MN, Bozlu M (2000) The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 86(4):490–493
doi: 10.1046/j.1464-410X.2000.00735.x pubmed: 10971279 pmcid: 10971279
Erginel B, Vural S, Akin M et al (2014) Wilms’ tumor: a 24-year retrospective study from a single center. Pediatr Hematol Oncol 31(5):409–414
doi: 10.3109/08880018.2014.930767 pubmed: 25007381 pmcid: 25007381
Pavan N, Bucci S, Mazzon G, Bertolotto M, Trombetta C, Liguori G (2015) It’s not always varicocele: a strange case of Zinner syndrome. Can Urol Assoc J 9(7-8):E535–E538
doi: 10.5489/cuaj.2451 pubmed: 26279734 pmcid: 26279734
Conzi R, Damasio MB, Bertolotto M et al (2017) Sonography of scrotal wall lesions and correlation with other modalities. J Ultrasound Med 36(10):2149–2163
doi: 10.1002/jum.14257 pubmed: 28556191 pmcid: 28556191
Secil M, Bertolotto M, Rocher L et al (2017) Imaging features of paratesticular masses. J Ultrasound Med 36(7):1487–1509
doi: 10.7863/ultra.16.07015 pubmed: 28370138 pmcid: 28370138
Yilmaz C, Arslan M, Arslan M (2009) Intrascrotal arteriovenous malformation simulating varicocele. AJR Am J Roentgenol 192(6):W351
doi: 10.2214/AJR.09.2476 pubmed: 19457805 pmcid: 19457805
Bhatt S, Jafri SZ, Wasserman N, Dogra VS (2011) Imaging of non-neoplastic intratesticular masses. Diagn Interv Radiol 17(1):52–63
pubmed: 20677130 pmcid: 20677130

Auteurs

Simon Freeman (S)

University Hospitals Plymouth NHS Trust, Derriford Hospital, Derriford Road, Crownhill, Plymouth, Devon, PL6 8DH, UK. simonfreeman@nhs.net.

Michele Bertolotto (M)

Department of Radiology, Ospedale di Cattinara, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.

Jonathan Richenberg (J)

Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE, UK.

Jane Belfield (J)

Royal Liverpool University Hospital, Prescot street, Liverpool, L7 8XP, UK.

Vikram Dogra (V)

Department of Radiology, University of Rochester, 601 Elmwood ave, Rochester, NY, 14642, USA.

Dean Y Huang (DY)

King's College Hospital NHS Foundation Trust, Department of Radiology, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.

Francesco Lotti (F)

Andrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini 6, I-50139, Florence, Italy.

Karolina Markiet (K)

Department of Radiology, Medical University of Gdansk, Mariana Smoluchowskiego 17, 80-214, Gdansk, Poland.

Olivera Nikolic (O)

Faculty of Medicine, Center of Radiology, Clinical Center of Vojvodina, University of Novi Sad, Hajduk Veljkova 1-9, Novi Sad, 21000, Serbia.

Subramaniyan Ramanathan (S)

Department of Clinical Imaging, Weill Cornell Medical College, Al-Wakra Hospital, Hamad Medical Corporation, PO Box 82228, Doha, Qatar.

Parvati Ramchandani (P)

Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Laurence Rocher (L)

Department of Adult Diagnostic and Interventional Radiology, Bicetre University Hospital, 78 avenue du Général Leclerc, 94270, Le Kremlin Bicêtre, France.
Imagerie par Résonance Magnétique Médicale et Multi-Modalités, CNRS UMR8081, Service Hospitalier Frédéric Joliot, 4, Place du Gal Leclerc, 91401, Orsay Cedex, France.

Mustafa Secil (M)

Faculty of Medicine, Department of Radiology, Dokuz Eylul University, Izmir, Turkey.

Paul S Sidhu (PS)

King's College Hospital NHS Foundation Trust, Department of Radiology, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.

Katarzyna Skrobisz (K)

Department of Radiology, Medical University of Gdansk, Mariana Smoluchowskiego 17, 80-214, Gdansk, Poland.

Michal Studniarek (M)

Department of Radiology, Medical University of Gdansk, Mariana Smoluchowskiego 17, 80-214, Gdansk, Poland.

Athina Tsili (A)

Department of Clinical Radiology, Medical School, University of Ioannina, University Campus, 45110, Ioannina, Greece.

Ahmet Tuncay Turgut (A)

Department of Radiology, Faculty of Medicine, Istinye University, Istanbul, Turkey.

Pietro Pavlica (P)

Private Hospital S.M. Maddalena, Occhiobello, Rovigo, Italy.

Lorenzo E Derchi (LE)

Department of Health Sciences (DISSAL), Emergency Radiology, University of Genoa, Policlinico San Martino, Largo R. Benzi, I16122, Genoa, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH