Synthesis and Evaluation of Diindole-Based MRI Contrast Agent for In Vivo Visualization of Necrosis.
Animals
Antineoplastic Agents, Phytogenic
/ pharmacology
Cell Line, Tumor
Contrast Media
/ chemical synthesis
Disease Models, Animal
Liver Neoplasms
/ diagnostic imaging
Lung Neoplasms
/ diagnostic imaging
Magnetic Resonance Imaging
/ methods
Male
Necrosis
Rats
Rats, Sprague-Dawley
Stilbenes
/ pharmacology
3,3′-diindolylmethane
Magnetic resonance imaging
Necrosis avid agent
Tumor necrosis
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
25
7
2019
medline:
3
6
2021
entrez:
24
7
2019
Statut:
ppublish
Résumé
Noninvasive imaging of cell necrosis can provide an early evaluation of tumor response to treatments. Here, we aimed to design and synthesize a novel diindole-based magnetic resonance imaging (MRI) contrast agent (Gd-bis-DOTA-diindolylmethane, Gd-DIM) for assessment of tumor response to therapy at an early stage. The oil-water partition coefficient (Log P) and relaxivity of Gd-DIM were determined in vitro. Then, its necrosis avidity was examined in necrotic cells in vitro and in rat models with microwave ablation-induced muscle necrosis (MAMN) and ischemia reperfusion-induced liver necrosis (IRLN) by MRI. Visualization of tumor necrosis induced by combretastatin A-4 disodium phosphate (CA4P) was evaluated in rats bearing W256 orthotopic liver tumor by MRI. Finally, DNA binding assay was performed to explore the possible necrosis-avidity mechanism of Gd-DIM. The Log P value and T1 relaxivity of Gd-DIM is - 2.15 ± 0.01 and 6.61 mM Gd-DIM may serve as a promising necrosis-avid MRI contrast agent for early assessment of tumor response to therapy.
Identifiants
pubmed: 31332630
doi: 10.1007/s11307-019-01399-2
pii: 10.1007/s11307-019-01399-2
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Contrast Media
0
Stilbenes
0
fosbretabulin
I5590ES2QZ
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
593-601Références
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