Expression of Long Non-Coding RNAs in Placentas of Intrauterine Growth Restriction (IUGR) Pregnancies.
IUGR
MALAT1
NEAT1
PANDA
Placenta
TUG1
Journal
Reports of biochemistry & molecular biology
ISSN: 2322-3480
Titre abrégé: Rep Biochem Mol Biol
Pays: Iran
ID NLM: 101637937
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
25
7
2019
Statut:
ppublish
Résumé
Intrauterine growth restriction (IUGR), a pathologic diminution of the rate of fetal growth, has been associated with alterations in expression of several genes. However, the role of long non-coding RNAs (lncRNAs) in its pathogenesis has not been studied. In this study we evaluated the expression of four lncRNAs namely, nuclear paraspeckle assembly transcript ( We found no significant differences in expression levels between cases and controls. We also found no correlation between expression and clinical data of study participants; however, we found significant correlations between expression levels of all the assessed lncRNAs in both cases and controls. These results imply the existence of a possible shared regulatory mechanism for the expression of these transcripts in placenta. Future studies are needed to perform such evaluations in larger sample sizes or in animal models in earlier stages of pregnancy.
Sections du résumé
BACKGROUND
BACKGROUND
Intrauterine growth restriction (IUGR), a pathologic diminution of the rate of fetal growth, has been associated with alterations in expression of several genes. However, the role of long non-coding RNAs (lncRNAs) in its pathogenesis has not been studied.
METHODS
METHODS
In this study we evaluated the expression of four lncRNAs namely, nuclear paraspeckle assembly transcript (
RESULTS
RESULTS
We found no significant differences in expression levels between cases and controls. We also found no correlation between expression and clinical data of study participants; however, we found significant correlations between expression levels of all the assessed lncRNAs in both cases and controls.
CONCLUSION
CONCLUSIONS
These results imply the existence of a possible shared regulatory mechanism for the expression of these transcripts in placenta. Future studies are needed to perform such evaluations in larger sample sizes or in animal models in earlier stages of pregnancy.
Types de publication
Journal Article
Langues
eng
Pagination
25-31Références
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