Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease.
Blood biomarkers
CSF P-Tau
CSF tau
Cognition
MRI
Plasma tau
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
24
7
2019
pubmed:
25
7
2019
medline:
25
7
2019
Statut:
epublish
Résumé
Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of combining plasma tau with CSF tau and phospho-tau (P-tau) are still unclear. Plasma-tau, CSF-tau, and P-tau were measured in 97 subjects, including elderly cognitively normal controls (n = 68) and patients with AD (n = 29) recruited at the NYU Center for Brain Health, with comprehensive neuropsychological and magnetic resonance imaging evaluations. Plasma tau was higher in patients with AD than cognitively normal controls ( Plasma tau is higher in AD independently from CSF-tau. Importantly, adding plasma tau to CSF tau or P-tau improves diagnostic accuracy, suggesting that plasma tau may represent a useful biomarker for AD, especially when added to CSF tau measures.
Identifiants
pubmed: 31334328
doi: 10.1016/j.dadm.2019.05.001
pii: S2352-8729(19)30038-7
pmc: PMC6624242
doi:
Types de publication
Journal Article
Langues
eng
Pagination
483-492Subventions
Organisme : NIA NIH HHS
ID : R01 AG013616
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008051
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062572
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG012101
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104127
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057848
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022374
Pays : United States
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