Therapeutic hypothermia: Applications in adults with acute ischemic stroke.

Hypothermia ischemia neuroprotection stroke

Journal

Brain circulation
ISSN: 2455-4626
Titre abrégé: Brain Circ
Pays: India
ID NLM: 101669876

Informations de publication

Date de publication:
Historique:
received: 24 02 2019
revised: 05 03 2019
accepted: 09 04 2019
entrez: 24 7 2019
pubmed: 25 7 2019
medline: 25 7 2019
Statut: ppublish

Résumé

The advent of mechanical thrombectomy and increasing alteplase use have transformed the care of patients with acute ischemic stroke. Patients with major arterial occlusions with poor outcomes now have a chance of returning to independent living in more than half of the cases. However, many patients with these severe strokes suffer major disability despite these therapies. The search is ongoing for agents that can be combined with thrombectomy to achieve better recovery through halting infarct growth and mitigating injury after ischemic stroke. Several studies in animals and humans have demonstrated that therapeutic hypothermia (TH) offers potential to interrupt the ischemic cascade, reduce infarct volume, and improve functional independence. We performed a literature search to look up recent advances in the use of TH surrounding the science, efficacy, and feasibility of inducing TH in modern stroke treatments. While protocols remain controversial, there is a real opportunity to combine TH with the existing therapies to improve outcome in adults with acute ischemic stroke.

Identifiants

pubmed: 31334356
doi: 10.4103/bc.bc_5_19
pii: BC-5-43
pmc: PMC6611191
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

43-54

Déclaration de conflit d'intérêts

There are no conflicts of interest.

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Auteurs

Andrea M Kuczynski (AM)

Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Andrew M Demchuk (AM)

Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Calgary, AB, Canada.

Mohammed A Almekhlafi (MA)

Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Department of Clinical Neurosciences, Hotchkiss Brain Institute, Calgary, AB, Canada.
O'Brien Institute for Public Health, Calgary, AB, Canada.

Classifications MeSH