Drug-Induced Fulminant Hepatitis in a Child Treated for Latent Multidrug-Resistant Tuberculosis With Dual Therapy Combining Pyrazinamide and Levofloxacin.
Antitubercular Agents
/ administration & dosage
Child
Drug Therapy, Combination
/ adverse effects
Humans
Latent Tuberculosis
/ complications
Levofloxacin
/ administration & dosage
Male
Massive Hepatic Necrosis
/ chemically induced
Pyrazinamide
/ administration & dosage
Tuberculosis, Multidrug-Resistant
/ complications
Journal
The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
25
7
2019
medline:
30
4
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.
Identifiants
pubmed: 31335574
doi: 10.1097/INF.0000000000002413
doi:
Substances chimiques
Antitubercular Agents
0
Pyrazinamide
2KNI5N06TI
Levofloxacin
6GNT3Y5LMF
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM