Anti-TSNARE1 IgG plasma levels differ by sex in patients with schizophrenia in a Chinese population.
ELISA
B lymphocytes
TSNARE1
autoantibodies
gender difference
schizophrenia
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
23
04
2019
revised:
03
07
2019
accepted:
22
07
2019
pubmed:
25
7
2019
medline:
6
5
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
It was recently reported that levels of plasma IgG antibodies against peptide antigens derived from proteins encoded by schizophrenia-associated genes are altered in individuals with schizophrenia treated with antipsychotics. This study aimed to replicate the initial finding in antipsychotic-naïve patients with first-episode schizophrenia and to explore the possible mechanism by which immune tolerance of B cells may be altered in this disease. A total of 408 case-control plasma samples were collected for analysis of circulating IgG antibodies against fragments derived from TCF4, TSNARE1, ZNF804A, TRANK1, ERCC4, DPYD and CD25 using an in-house ELISA. The Mann-Whitney U-test revealed that patients with schizophrenia had a significant change in plasma anti-TSNARE1 and anti-CD25 IgG levels; male patients mainly contributed to the increased levels of anti-TSNARE1 IgG and anti-CD25 IgG. Receiver operating characteristic (ROC) curve analysis revealed that the anti-TSNARE1 IgG assay had an area under the ROC curve of 0.625 with a sensitivity of 15.7% and a specificity of 95.2%. Work on a B-cell model revealed that TRANK1-derived antigen treatments could enhance the proportions of CD83+ cells and apoptotic B cells when compared with TSNARE1-derived antigen and vehicle treatment. We conclude that there is a gender difference in autoimmune responses in schizophrenia and suggest that anti-TSNARE1 IgG may be indicative of schizophrenia in a subgroup of male patients.
Identifiants
pubmed: 31336035
doi: 10.1002/2211-5463.12704
pmc: PMC6768289
doi:
Substances chimiques
Immunoglobulin G
0
SNARE Proteins
0
TSNARE1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1705-1712Informations de copyright
© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
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