Ureidobenzenesulfonamides as efficient inhibitors of carbonic anhydrase II.
Carbonic anhydrase
Glaucoma
Inhibitor
Urea
Ureidobenzenesulfonamide
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
09
01
2019
revised:
04
07
2019
accepted:
11
07
2019
pubmed:
25
7
2019
medline:
30
9
2020
entrez:
24
7
2019
Statut:
ppublish
Résumé
Sulfonamides represent an important class of drugs because of their inhibitory effect on carbonic anhydrases (CAs). We therefore synthesized several ureidobenzenesulfonamides and evaluated their bCA II inhibition for their potential use as anti-glaucoma gents. Since these compounds must not show cytotoxic effects, their cytotoxic potential against several human tumor cell lines and non-malignant fibroblasts was investigated. Several fluorophenyl substituted sulfonamides were efficient inhibitors of bCA II. Only one benzylphenyl substituted sulfonamide, however, showed a remarkable selectivity for HT29 colorectal carcinoma cells while being significantly less cytotoxic to non-malignant fibroblasts.
Identifiants
pubmed: 31336306
pii: S0045-2068(19)30036-7
doi: 10.1016/j.bioorg.2019.103123
pii:
doi:
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Phenylurea Compounds
0
Sulfonamides
0
Carbonic Anhydrase II
EC 4.2.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103123Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.